Identifying genes linked to behaviors in substance use disorders
Official title: Integrating genetic and circuit variation to identify genes involved in behaviors related to substance use disorder
Funded at University of California Los Angeles · NIH-11192880 · Data updated 2026-11-12
This study is looking at how our genes might affect behaviors related to substance use disorders by examining a brain circuit linked to anxiety, and it’s designed to help us understand more about the biology behind these challenges.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 15, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $705,965 |
| NIH project number | 5U01DA059695-02 |
| Project ID | NIH-11192880 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of substance use disorders or related anxiety disorders.
✕Less likely to help
Patients who do not have substance use disorders or related behavioral issues may not benefit from this research.
What this research studies
This research aims to uncover the genetic factors that influence behaviors associated with substance use disorders (SUD) by using a novel approach that connects brain circuit activity to genetic mapping. Researchers will study a specific brain circuit involved in anxiety-related behaviors, which often co-occur with SUD. By activating this circuit in various mouse strains, they will observe differences in behavior that can be traced back to genetic variations. The project involves detailed genetic mapping and testing to identify the specific genes that contribute to these behaviors, potentially leading to new insights into the biological underpinnings of SUD.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the genetic factors that contribute to substance use disorders, paving the way for more effective treatments.
How similar studies have gone: Previous research has shown promise in using genetic mapping to understand behavioral traits, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Flint, Jonathan — University of California Los Angeles
- Study coordinator: Flint, Jonathan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.