Identifying genes linked to behaviors in substance use disorders
Integrating genetic and circuit variation to identify genes involved in behaviors related to substance use disorder
['FUNDING_U01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11192880
This study is looking at how our genes might affect behaviors related to substance use disorders by examining a brain circuit linked to anxiety, and it’s designed to help us understand more about the biology behind these challenges.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11192880 on ClinicalTrials.gov |
What this research studies
This research aims to uncover the genetic factors that influence behaviors associated with substance use disorders (SUD) by using a novel approach that connects brain circuit activity to genetic mapping. Researchers will study a specific brain circuit involved in anxiety-related behaviors, which often co-occur with SUD. By activating this circuit in various mouse strains, they will observe differences in behavior that can be traced back to genetic variations. The project involves detailed genetic mapping and testing to identify the specific genes that contribute to these behaviors, potentially leading to new insights into the biological underpinnings of SUD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of substance use disorders or related anxiety disorders.
Not a fit: Patients who do not have substance use disorders or related behavioral issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the genetic factors that contribute to substance use disorders, paving the way for more effective treatments.
How similar studies have performed: Previous research has shown promise in using genetic mapping to understand behavioral traits, suggesting that this approach could yield valuable insights.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FLINT, JONATHAN — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: FLINT, JONATHAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.