Condition

Speech clinical trials and research

• 12Clinical trials
• 251NIH research projects
• 4Countries

Newest Speech clinical trials

All recruiting trials (12)

• Virtual reality training for public speaking in higher-education students

  This project tests whether virtual reality practice combined with voice and fluency training helps French-speaking higher-education students improve their public speaking.

  Recruiting University of Liege · Liège, Liège · NCT07392554

• Evaluating speech performance with titanium partial dentures

  This study is testing if new lightweight titanium partial dentures can help people with missing teeth speak more clearly compared to traditional dentures.

  Recruiting Badr University · Cairo · NCT06589570

• Speech motor learning and retention in adults using brain stimulation and fMRI

  This study tests whether learning new speech movements and retaining them depend on brain areas beyond the mouth and speech muscles, by using brain stimulation and brain imaging to see how the brain changes relate to getting and keeping new speech skills.

  Recruiting Yale University · New Haven, Connecticut · NCT06492252

• Understanding how the brain learns and retains speech motor skills

  This study is trying to see how different parts of the brain help people learn and remember how to speak by using special techniques to look at brain activity.

  Recruiting Yale University · New Haven, Connecticut · NCT06491823

• Enhancing early language development in infants through caregiver interaction

  This study is testing if a program that helps caregivers talk more with their babies can improve language skills in infants aged two to six months from at-risk families.

  Recruiting IDeA States Pediatric Clinical Trials Network · Kansas City, Kansas and 1 other locations · NCT06479278

• Testing a new model of speech motor learning and retention

  This study is testing a new way to help people learn and remember how to speak by looking at how different parts of the brain work together during speech practice.

  Recruiting Yale University · New Haven, Connecticut · NCT06467305

• Testing a new model for learning and retaining speech motor skills

  This study is testing a new way to help people learn and remember how to speak by looking at how different parts of the brain work together during speech practice.

  Recruiting Yale University · New Haven, Connecticut · NCT06467292

• Understanding how the brain controls speech in healthy individuals

  This study is trying to understand how healthy people control their speech by looking at how they adapt their speaking when they hear changes in their own voice.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT06233513

• Evaluating how fixing crossbites affects children's speech

  This study tests if fixing crossbites in children aged 8 to 10 can improve their speech and overall quality of life.

  Recruiting Tanta University · Tanta, Gharbia Governorate · NCT06168695

• Investigating how hearing ourselves speak affects speech movements

  This study is testing how hearing ourselves talk affects our speech movements in both regular speakers and patients with brain implants to see how it influences how we adjust our speech.

  Recruiting University of Washington · Seattle, Washington · NCT06164717

• Investigating how clear speech affects listening effort and memory in older adults with hearing loss

  This study is testing how clear speech affects how hard older adults with hearing loss have to work to listen and remember what they hear.

  Recruiting University of Utah · Salt Lake City, Utah · NCT06053190

• Topical gel and mouthwash to prevent severe oral mucositis in people receiving head and neck radiation

  This will test whether a topical gel and mouthwash (XCM-OM118) can reduce severe oral mucositis and improve quality of life for adults having radiation for head and neck cancer.

  Recruiting Mucosa Innovations, S.L. · Madrid, Madrid · NCT05635929

NIH-funded research (newest 40 of 251)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Silent speech interface using a wearable tongue tracker to help people after laryngectomy communicate

  A wearable system with tongue sensors and intraoral components aims to let people without a vocal cord use natural-sounding speech in daily life.

  NIH research University of Texas at Austin · Austin, United States · NIH-11603090

• Overlap between how we speak and how we hold words in memory

  A Duke-led project studies how the brain that talks relates to keeping verbal information in working memory, using advanced brain recordings from patients already undergoing medical care.

  NIH research Duke University · Durham, United States · NIH-11598542

• AI-powered system to improve teamwork in cardiac surgery

  A research project is testing an AI-driven system that listens to team conversations during heart surgeries to spot teamwork patterns and give real-time feedback to improve patient safety.

  NIH research University of Colorado · Boulder, UNITED STATES · NIH-11579799

• Caregiver Speech and Infant Brain Development in Siblings of Children with Autism

  This project follows babies who have an older sibling with autism to explore how caregiver talk and everyday interactions relate to early brain and behavior development.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11540457

• How speech and swallowing work in people with Down syndrome

  Researchers will look at how differences in the mouth, throat, and brain affect speech clarity and safe swallowing in children and adults with Down syndrome.

  NIH research Pennsylvania State University, the · University Park, United States · NIH-11508105

• Information and social media use for autism info in young children

  A research project looks at how speech-language pathologists and parents of young autistic children use social media for information and what makes that information trustworthy.

  NIH research Michigan State University · East Lansing, United States · NIH-11452950

• Prosody and Speech: How Prosody and Speaking Sounds Come Together in the Brain

  This project asks how the brain plans and coordinates the rhythm and tone of speech, especially in people who stutter, using brain scans and speech experiments.

  NIH research Boston University (Charles River Campus) · Boston, United States · NIH-11449873

• Remote AI-guided speech cues to help people with Parkinson’s speak more clearly

  A remote AI-based tool uses a web camera to give personalized speech cues to adults with Parkinson’s to improve how clearly they talk.

  NIH research University of Wyoming · Laramie, United States · NIH-11443212

• Understanding Early Speech Paths to Predict Later Outcomes in Late-Talking Toddlers

  This project looks at how early vocal development in toddlers who are late in speaking can forecast language and achievement later on.

  NIH research Emory University · Atlanta, United States · NIH-11427795

• Early detection of Alzheimer’s and related dementia using speech from hearing aids

  This project explores whether non-semantic speech patterns and acoustic features from hearing aid users can help detect and monitor Alzheimer’s disease and related dementias early on.

  NIH research Headwaters Innovation, INC. · Inver Grove Heights, UNITED STATES · NIH-11416519

• Predicting How Real-World Noise Affects Speech Understanding

  Aims to improve our understanding of how people, especially older adults and those with hearing loss, understand speech in everyday noisy environments by using advanced models of natural background sounds.

  NIH research University of Connecticut Storrs · Storrs-Mansfield, United States · NIH-11411403

• Caregiver-led early speech help for toddlers with cleft palate

  A caregiver-implemented, telehealth-based program teaches families how to support their toddler’s speech and language development in English and Spanish.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11408827

• Speech-prosthesis that reads brain signals to let ALS patients type fast

  A project to develop a brain-controlled voice device for people with ALS to type quickly using signals from the brain.

  NIH research Stanford University · Stanford, United States · NIH-11408820

• AI-powered speech annotation and transcription enhancer tool for pediatric use

  A pediatric-focused AI tool helps speech-language pathologists automatically analyze kids’ speech to save time and improve accuracy.

  NIH research Auspex Medix, LLC · Williamsville, United States · NIH-11407819

• Preschool speech and early literacy support with AI-powered classroom and home game

  A new program helps 2–6 year-olds improve speech and early reading by connecting classroom teaching with an interactive AI-powered home game.

  NIH research Finnegan the Dragon, INC · Hillsboro, United States · NIH-11405682

• Intraoral wearable with a tongue-based interface to control devices for people with cervical spinal cord injuries or ALS

  A small mouth-held device lets a user move a cursor and operate devices with their tongue, helping people with quadriplegia communicate and interact more easily.

  NIH research Augmental Technologies INC. · San Francisco, United States · NIH-11403178

• Understanding how speech develops in kids who use two dialects or languages

  We’re studying how young children who speak two dialects or languages produce speech sounds, to help clinicians tell apart typical differences from speech delays.

  NIH research University of Toronto · Toronto, Canada · NIH-11402806

• Subcortical Circuits and Speech Sequencing in Deep Brain Stimulator Recipients

  This project looks at how deep brain stimulation in people with certain brain disorders affects how they learn and produce sequences of speech.

  NIH research Boston University (Charles River Campus) · Boston, United States · NIH-11398995

• Restoring speech with a brain implant for stroke-related aphasia

  A study at UC Davis aims to help people who have language trouble after a stroke by using a tiny brain implant to turn brain signals into spoken words.

  NIH research University of California at Davis · Davis, United States · NIH-11397115

• Digital speech markers to track bulbar decline in Spanish-speaking ALS patients

  A smartphone app will collect Spanish-language speech data from ALS patients to detect early bulbar decline and help guide timely care.

  NIH research Nova Southeastern University · Fort Lauderdale-Davie, UNITED STATES · NIH-11393889

• Understanding how the brain stops speaking mid-sentence in autism-related speech

  This research explores how the brain rapidly halts ongoing speech, which could help people with autism spectrum disorders who struggle with communication.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11393176

• Cortical ways we plan speech in healthy people and Parkinson’s

  Researchers are studying how the brain plans speech in people with and without Parkinson’s disease to understand why speech may be harder for some individuals.

  NIH research New York University School of Medicine · New York, United States · NIH-11391876

• Augmented speech training to boost how adults learn clear speech

  This project tests visually guided speech training to help adults with speech motor learning improve how they speak clearly.

  NIH research Arizona State University-Tempe Campus · Scottsdale, United States · NIH-11391393

• Auditory-perceptual speech features in preschoolers to differentiate CAS and dysarthria

  A new project will help young children who have suspected motor speech disorders by identifying clear speech feature patterns to tell CAS from dysarthria.

  NIH research Northeastern University · Boston, United States · NIH-11384853

• Precision view of how your voice works and sounds when speaking

  A research project at Michigan State University will study how vocal folds move and how voice sounds are perceived during everyday speech, with the goal of improving diagnosis and treatment of voice disorders.

  NIH research Michigan State University · East Lansing, United States · NIH-11379998

• Vital signs for psychosis: personalized, always-on markers from speech and language

  A patient-friendly approach to using speech and language cues to measure psychosis severity over time, so clinicians can tailor care.

  NIH research Feinstein Institute for Medical Research · Manhasset, United States · NIH-11378668

• How our own speech changes what we hear in the brain

  This project uses brain imaging to understand how speaking alters how we hear sounds, aiming to map the brain circuits involved in speech and listening.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11378545

• How early hearing access shapes babies' speech sound learning

  This project looks at how differences in hearing access affect speech-sound learning in infants who are hard-of-hearing compared with infants who hear normally.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11376992

• Improving how adults remember speech sounds, with or without language disorder

  This project tests different training schedules to help adults remember speech sounds better, including those with developmental language disorder (DLD).

  NIH research University of Delaware · Newark, UNITED STATES · NIH-11374860

• Speech tools to spot hospital or ER risk during home nursing visits

  The project uses computer analysis of nurse-patient conversations during home healthcare to find people at higher risk of hospitalization or emergency department visits.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11370222

• Differentiating Speech Delays from Dysarthria in Children with Cerebral Palsy

  Aims to create easy-to-use, data-driven standards to tell apart typical speech development from dysarthria in young children with cerebral palsy so clinicians can identify and help earlier.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11367975

• Predicting which speech sound delays persist or improve in young children

  This project looks at 4-year-olds with speech sound difficulty to predict who will still have it at age 7 and how to tailor better therapy.

  NIH research Purdue University · West Lafayette, United States · NIH-11367761

• Understanding how context shapes speech processing in autism

  A study to learn how people with autism process speech differently in real-life listening situations.

  NIH research Northwestern University · Chicago, United States · NIH-11367407

• Speech, brain development, and anesthesia in infants with cleft lip/palate

  This study follows infants with isolated cleft lip/palate to understand how early brain development and language skills relate to anesthesia exposure and oxygenation during early life.

  NIH research University of Iowa · Iowa City, United States · NIH-11365841

• Overlap between speaking and holding words in memory

  A Duke University study will look at how our brain keeps and uses spoken information in short-term memory to help us talk smoothly in real life, especially in noisy or changing conversations.

  NIH research Duke University · Durham, United States · NIH-11365837

• DTTC-Connect: Helping kids with speech bring phrases to life

  A child-focused trial tests a new DTTC-based method, DTTC-Connect, to improve connected speech in kids with childhood apraxia of speech.

  NIH research New York University · New York, United States · NIH-11364832

• Predicting rehospitalization and disengagement in psychosis using automated speech and language analysis

  A research project uses voice and language patterns to forecast which people with psychosis in coordinated specialty care might be readmitted to hospital or stop continuing treatment.

  NIH research Feinstein Institute for Medical Research · Manhasset, United States · NIH-11362325

• How the brain understands spoken language in autism

  Researchers study how the brain processes speech sounds so people with autism may benefit from improved communication therapies in the future.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11361054

• Microvascular brain health and speech in people at risk for Alzheimer’s disease

  This study will look at how tiny blood vessels in the brain relate to speech and thinking changes in adults at risk for Alzheimer’s disease.

  NIH research Mgh Institute of Health Professions · Charlestown, UNITED STATES · NIH-11360881

• Understanding how the brain turns speech into meaning

  A big neuroscience question is being studied to explain how adults process natural speech in real life, with findings that could help people who struggle to understand spoken language.

  NIH research University of Rochester · Rochester, United States · NIH-11354007

Related topics

Quick answers

How many Speech clinical trials are recruiting right now?

12, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (8 trials), Egypt (2 trials), Belgium (1 trial), Spain (1 trial). Each study page lists its sites and which ones are recruiting.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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