Microvascular brain health and speech in people at risk for Alzheimer’s disease

Who could benefit from this research

What this research studies

If you are 65 or older and have risk factors for Alzheimer’s disease, researchers will use noninvasive brain imaging and speech measurements to explore how blood flow in the brain relates to how you speak and move. They will analyze acoustic and movement data from speech alongside MRI-based measures of cerebral blood flow to see if patterns differ by genetic risk (APOE-ε4). The goal is to identify early, easy-to-measure signals that could indicate who is at higher risk before more obvious symptoms appear. Participation would involve visits for MRI scans and simple speech tasks. This work could pave the way for earlier detection and monitoring of brain health in aging adults at risk for AD.

Why it matters

Where this research is happening

• Mgh Institute of Health Professions
  Charlestown, United States Active

Researchers

• Principal investigator: Eshghi, Marziye — Mgh Institute of Health Professions
• Study coordinator: Eshghi, Marziye

Related research

Other NIH-funded projects on the same topics.

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• Using speech patterns to find early signs of Alzheimer's disease

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• Thiamine-boosting therapy for Alzheimer’s: understanding how benfotiamine may reduce harmful AGE in DP patients

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.