Condition

Oral Mucositis clinical trials and research

• 14Clinical trials
• 12NIH research projects
• 14Countries

Newest Oral Mucositis clinical trials

All recruiting trials (14)

• Copaiba Mouthwash with Low-Level Laser Therapy to Prevent Mouth Sores After Stem Cell Transplant

  This phase 2 trial tests whether a copaíba-based mouthwash, used four times daily, can help prevent oral mucositis in patients undergoing autologous hematopoietic stem cell transplantation.

  Recruiting Phase 2 Instituto Nacional de Cancer, Brazil · Rio de Janeiro, Rio de Janeiro · NCT07810530

• Chlorophyllin to reduce mouth sores before allogeneic stem cell transplant

  This phase II study tests whether taking chlorophyllin by mouth can lower the chances and severity of mouth ulcers in patients aged 12–65 undergoing radiation-based conditioning before a first allogeneic stem cell transplant.

  Recruiting Phase 2 Tata Memorial Centre · Navi Mumbai, Maharashtra · NCT07709195

• BupiZenge vs Lidocaine for mouth pain from oral mucositis in head and neck cancer

  A phase 3 trial tests whether the BupiZenge lozenge provides better pain relief than lidocaine for mouth sores caused by radiation in head and neck cancer patients.

  Recruiting at 9 sites Phase 3 OncoZenge AB · Copenhagen and 10 other locations · NCT07672236

• Ozone gas plus biomimetic toothpaste and mouthwash to treat cancer therapy mouth sores

  This trial will test whether adding a biomimetic toothpaste and mouthwash to ozone gas therapy helps adults with chemo- or radiotherapy-induced mouth sores heal faster and have less pain.

  Recruiting University of Pavia · Pavia, Lombardy · NCT07491536

• High-level laser therapy for oral mucositis in children receiving hematopoietic stem cell transplant

  This trial tests whether high-level laser therapy can reduce the pain and severity of oral mucositis in children undergoing hematopoietic stem cell (bone marrow) transplantation.

  Recruiting Ain Shams University · Cairo, Cairo Governorate · NCT07436650

• Amimestrocel infusion to prevent severe mouth sores after allogeneic stem cell transplant

  This study will try a single IV infusion of Amimestrocel in adults receiving myeloablative allogeneic stem cell transplants with TBI or melphalan to see if it prevents severe mouth sores.

  Recruiting Phase 2 The First Affiliated Hospital of Soochow University · Suzhu, Jiangsu · NCT07400328

• Low-level laser (photobiomodulation) to prevent mouth sores during radiotherapy for oral cancer

  This study will try low-level laser therapy (photobiomodulation), given five times a week during radiotherapy, to reduce mouth sores in adults treated for oral cancer.

  Recruiting Peter MacCallum Cancer Centre, Australia · Melbourne, Victoria · NCT07387978

• Comparing treatments for oral mucositis in children undergoing chemotherapy

  This study tests whether sodium bicarbonate, saline, or black mulberry syrup can help reduce mouth sores in children aged 6-18 who are getting chemotherapy.

  Recruiting Burdur Mehmet Akif Ersoy University · Isparta · NCT06525402

• Using Telehealth to Enhance Oral Health for Cancer Survivors

  This study tests whether using telehealth can help cancer survivors improve their oral health and prevent problems after their treatment.

  Recruiting Georgetown University · Washington D.C., District of Columbia · NCT06315855

• Preventing oral mucositis in head and neck cancer patients

  This study tests if a zinc spray can help prevent painful mouth sores in patients with head and neck cancer who are getting radiation treatment.

  Recruiting Catholic University of the Sacred Heart · Roma, Italy · NCT05853692

• Topical gel and mouthwash to prevent severe oral mucositis in people receiving head and neck radiation

  This will test whether a topical gel and mouthwash (XCM-OM118) can reduce severe oral mucositis and improve quality of life for adults having radiation for head and neck cancer.

  Recruiting Mucosa Innovations, S.L. · Madrid, Madrid · NCT05635929

• Using coconut oil mouth rinse to prevent mouth sores in kids undergoing chemotherapy

  This study is testing if using a mouth rinse made from coconut oil can help prevent mouth sores in kids and young adults undergoing chemotherapy.

  Recruiting Phase 2 Wake Forest University Health Sciences · Charlotte, North Carolina · NCT05441813

• Using light therapy to prevent mouth sores in patients getting stem cell transplants

  This study is testing if a special light therapy can help prevent mouth sores in patients getting stem cell transplants.

  Recruiting Dana-Farber Cancer Institute · Boston, Massachusetts · NCT05335434

• Treatment of oral mucositis caused by chemotherapy and radiation

  This study is testing if a new mouth solution called Orosol® can help people with painful mouth sores caused by chemotherapy and radiation feel better and heal faster.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand and 1 other locations · NCT05161091

NIH-funded research (12)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how biological sex affects radiation-induced oral mucositis

  This grant explores why women and men experience different severity of mouth sores during head and neck cancer radiotherapy and how to tailor treatments to reduce pain and healing time.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11435474

• First-in-human topical gel for preventing and treating radiation-induced oral ulcers in cancer patients

  A new oral gel applied to the mouth is being tested to prevent and treat painful mouth ulcers caused by cancer radiation therapy, with early safety and dosing data gathered in people.

  NIH research Allander Biotechnologies, INC. · Aurora, United States · NIH-11411493

• New medicine to prevent or lessen painful mouth sores from radiation

  This project develops a potential drug to prevent or shorten painful mouth sores that happen after radiation therapy for head and neck cancer.

  NIH research Sinopia Biosciences, INC. · San Diego, United States · NIH-11349200

• Protecting the mouth from radiation in head and neck cancer

  A Duke University-based study looks at how the p53 protein may guard the mouth from radiation-related damage in people with head and neck cancer.

  NIH research Duke University · Durham, United States · NIH-11335599

• Prophylactic and therapeutic oral gel to prevent and treat radiation-induced mouth ulcers in cancer patients

  A new topical gel shown in animals may prevent or treat painful mouth ulcers caused by cancer radiation therapy, with plans to move toward human testing.

  NIH research Allander Biotechnologies, INC. · Aurora, United States · NIH-11321353

• A new medicine to prevent and treat radiation-related mouth sores

  A new oral drug is being developed to prevent or shorten painful mouth sores in people getting radiation to the head and neck.

  NIH research Sinopia Biosciences, INC. · San Diego, United States · NIH-11182472

• Understanding and treating pain and mouth sores from radiation for head and neck cancer

  This work explores new ways to relieve the burning pain and mouth sores that often happen after radiation therapy for head and neck cancer.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11127572

• Protecting the Mouth from Radiation Side Effects

  This project looks for ways to protect the mouth from painful sores that can happen during radiation treatment for head and neck cancer.

  NIH research Duke University · Durham, United States · NIH-11111172

• Targeting specific nerves to reduce pain and mouth sores from radiation therapy

  This study is looking at how to help people with head and neck cancer who experience painful mouth sores and burning pain during radiation therapy, by exploring new ways to ease their discomfort and improve their quality of life.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10950683

• Developing a new treatment for severe mouth sores in cancer patients

  This study is testing a new gel treatment for mouth sores that can happen during cancer radiation therapy, aiming to help patients heal better and feel more comfortable while they receive their treatment.

  NIH research Allander Biotechnologies, INC. · Aurora, United States · NIH-10933015

• How p53 can protect against mouth sores caused by radiation therapy

  This study is looking at how a protein called p53 can help prevent painful mouth sores that sometimes happen after radiation treatment for head and neck cancer, with the hope of finding better ways to manage these side effects while still treating the cancer effectively.

  NIH research Duke University · Durham, United States · NIH-10924014

• Testing a new treatment for mouth sores caused by radiation therapy

  This study is looking at a new treatment to help prevent and ease the painful mouth sores that many cancer patients get from radiation therapy, using a special compound that has shown promise in early tests.

  NIH research Sinopia Biosciences, INC. · San Diego, United States · NIH-10822803

Related topics

Quick answers

How many Oral Mucositis clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in United States (3 trials), Italy (2 trials), Brazil (1 trial), Egypt (1 trial), Denmark (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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