NIH-funded research R01 grant

Prosody and Speech: How Prosody and Speaking Sounds Come Together in the Brain

Official title: Sequencing and Initiation in Speech Production

Funded at Boston University (Charles River Campus) · NIH-11449873 · Data updated 2026-11-12

This project asks how the brain plans and coordinates the rhythm and tone of speech, especially in people who stutter, using brain scans and speech experiments.

More Speech research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionBoston University (Charles River Campus)
NIH-funded
Lab location1 site (Boston, United States)
Project startApril 1, 2006
Project endJune 30, 2031
Funding year2026
Award (this year)$690,517
NIH project number2R01DC007683-21
Project IDNIH-11449873 on NIH RePORTER

Who could benefit from this research

Could help

Adults who stutter and adults without stuttering, ages 21 and older, willing to participate in speaking tasks and MRI sessions.

Less likely to help

Individuals who cannot undergo MRI scanning or who have no interest in speech tasks would not benefit.

What this research studies

If you speak, your brain combines the melody of speech (intonation and rhythm) with the sounds of words. The study tests how this blending happens in healthy adults versus adults who stutter, using fMRI, detailed speech recordings, and computer models. Participants will repeat simple sentences and then change the prosodic parts before repeating, allowing researchers to see how prosody and segments interact. The team compares two prosody aspects (metrical and intonational) and looks at how these interact with word content. This could explain why some people stutter and guide new approaches to help them speak more smoothly.

Why it matters

Potential benefit: Understanding these brain mechanisms could lead to better therapies for stuttering and more natural-sounding speech therapies.

How similar studies have gone: Past work supports that prosody and speech planning involve specific brain networks, though the exact interactions in stuttering are still being explored.

Where this research is happening

  • Boston University (Charles River Campus)
    Boston, United States
    Active

Researchers

  • Principal investigator: Guenther, Frank H — Boston University (Charles River Campus)
  • Study coordinator: Guenther, Frank H

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.