Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Non-invasive craniocervical lymphatic drainage to improve memory and thinking after sleep loss

Official title: Effects of Non-Invasive Superficial Craniocervical Lymphatic Drainage (NSCLD) on Memory and Cognitive Function in Adults With Sleep Deprivation: A Proof-of-Concept Study

Run by The George Institute · NCT07084701 · Data updated 2026-11-12

This trial will try a gentle, non-invasive craniocervical lymphatic drainage technique to see if it improves memory and thinking in adults who are sleep-deprived.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment30 (estimated)
SponsorThe George Institute
Academic / other
Locations1 site (Tianjin)
StatusRecruiting
StartedSeptember 15, 2025
Main results expectedJune 2026
Study endsDecember 2026
Registry record updatedJanuary 13, 2026
Trial IDNCT07084701 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are healthy college students aged 18 or older who are currently experiencing sleep deprivation and are not pregnant, breastfeeding, or taking medications that influence memory or cognition.

Probably not a fit

Patients with chronic sleep disorders, uncontrolled medical conditions, prior craniocervical trauma or surgery, pregnancy or breastfeeding, or inability to complete cognitive testing are unlikely to benefit from this intervention.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This proof-of-concept interventional study applies a non-invasive superficial craniocervical lymphatic drainage (NSCLD) procedure to adults experiencing sleep deprivation. Participants receive either NSCLD or a sham intervention and complete standardized memory and cognitive tests before and after treatment. The study enrolls healthy college-aged adults free of major medical or psychiatric conditions and excludes pregnant or breastfeeding individuals and those taking medications that affect cognition. Primary outcomes focus on short-term changes in attention, working memory, and executive function associated with the intervention.

Why it matters

Potential benefit: If successful, NSCLD could offer a quick, non-drug option to reduce short-term memory and cognitive problems caused by sleep loss.

How similar studies have gone: The approach is relatively novel in humans: preclinical and early translational work on the glymphatic system offers theoretical support, but controlled clinical evidence that lymphatic drainage improves cognition after sleep loss is limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* College student ≥18 years, all of whom have passed a standardized entrance examination;
* No failed exams during the course of study;
* Sleep deprivation;
* In good health, with no mental or psychological disorders;
* No recent use of medications that may affect memory and cognition;
* Voluntary participation and able to undergo cognitive function and memory testing;
* Informed consent provided

Exclusion Criteria:

* Pregnant or breastfeeding women.
* Presence of acute or chronic medical conditions (e.g., severe hypertension, diabetes, cardiovascular disease) that could confound the results.
* History of craniocervical trauma or surgery.
* Current use of sedative or anxiolytic medications that could influence sleep or cognitive function.
* Participants who are unable to follow the procedures or complete the assessments

Where it's running

  • Tianjin Medical University General Hospital
    Tianjin, China
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.