Effects of Sleep Deprivation on Itch and Pain Sensitivity

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This experiment investigates how sleep deprivation influences itch and pain sensitivity in healthy participants. It aims to compare the effects of sleep fragmentation on both sensations and evaluate the inflammatory response by measuring C-reactive protein levels in blood samples. Additionally, the study will assess the correlation between anxiety and depression scores and their impact on itch and pain sensitivity. The findings could provide insights into the relationship between sleep quality and chronic itch, which affects a significant portion of the population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy men and women
* 18-60 years
* Speak and understand English
* Access to a smartphone during the experimental nights

Exclusion Criteria:

* Pregnancy or lactation
* Drug addiction defined as any use of cannabis, opioids, or other drugs
* Previous or current history of neurological, dermatological, immunological musculoskeletal, cardiac disorder or mental illnesses (psychiatric diagnosis) that may affect the results (e.g., neuropathy, muscular pain in the upper extremities, anxiety, depression, schizophrenia etc.)
* Moles, wounds, scars, or tattoos in the area to be treated or tested
* Current use of medications that may affect the trial such as antihistamines and pain killers.
* Skin diseases
* Consumption of alcohol or painkillers 24 hours before the study days and between these
* Acute or chronic pain and itch
* Participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical studies)
* Lack of ability to cooperate

Where it's running

• Aalborg University
  Aalborg, Denmark Recruiting

Study contacts

• Study coordinator: kristian KS Petersen
• Email: KKP@hst.aau.dk
• Phone: 31697510

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Exploring how catastrophizing affects itch perception in healthy individuals

  This study is testing how different ways of thinking about pain and discomfort, like feeling helpless or worrying too much, affect how healthy people experience itchiness.

  Recruiting Aalborg University · Aalborg, Denmark · NCT06340438

• Sleep and circadian care for ICU patients

  This study tests a multicomponent sleep and circadian rhythm program in adult ICU patients to see if it helps keep daily rhythms and sleep better.

  Recruiting Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT07869901

• HBS-104 single doses in acutely sleep-deprived healthy adults

  This study tests whether a single dose of HBS-104 is safe and how it behaves in the body when given to healthy adults who are acutely sleep-deprived.

  Recruiting Phase 1 Harmony Biosciences Management, Inc. · Eatontown, New Jersey · NCT07848659

• Mind After Midnight — how being awake between 2:00 and 4:00 AM affects mood and decision-making

  This project will test whether being awake during the biological night (2:00–4:00 AM) increases negative mood, poor decision-making, and suicidal thoughts in adults who have had suicidal ideation in the past six months.

  Recruiting University of Arizona · Tucson, Arizona · NCT07438912

• Nighttime synchronization of eating and your circadian clock

  This trial will test whether changing light exposure and when you eat during short sleep periods changes metabolism in healthy adults aged 18–35 who normally sleep 7–9 hours per night.

  Recruiting University of Utah · Salt Lake City, Utah · NCT07329283

• How the body clock affects time perception during 36 hours awake

  This test will see if the internal body clock and staying awake for about 36 hours change how healthy adults experience and estimate time.

  Recruiting University of Aarhus · Aarhus · NCT07294781

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.