Understanding how lack of sleep affects decision-making in the brain.
THE ROLE OF MEDIUM SPINY NEURONS IN SLEEP DEPRIVATION-INDUCED COGNITIVE RIGIDITY.
['FUNDING_R21'] · WASHINGTON STATE UNIVERSITY · NIH-10791860
This study looks at how not getting enough sleep affects our ability to make decisions when things change, using mice and rats to explore what happens in their brains when they're sleep-deprived, so we can learn more about why we might struggle to adapt when we're tired.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON STATE UNIVERSITY (nih funded) |
| Locations | 1 site (PULLMAN, UNITED STATES) |
| Trial ID | NIH-10791860 on ClinicalTrials.gov |
What this research studies
This research investigates how sleep deprivation impacts cognitive flexibility, which is the ability to adapt decision-making in changing situations. By studying specific brain cells in mice and rats, the researchers aim to uncover the biochemical and electrical changes that occur in the brain due to lack of sleep. The study employs advanced techniques like electrophysiology and real-time imaging to observe these changes and their effects on behavior. The goal is to better understand the underlying mechanisms that lead to cognitive rigidity when sleep is insufficient.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing cognitive difficulties related to sleep deprivation, such as shift workers or those with sleep disorders.
Not a fit: Patients who do not experience cognitive rigidity or sleep-related decision-making issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving cognitive function in individuals suffering from sleep deprivation.
How similar studies have performed: Previous research has shown promising results in understanding the effects of sleep deprivation on cognitive function, making this approach both relevant and potentially impactful.
Where this research is happening
PULLMAN, UNITED STATES
- WASHINGTON STATE UNIVERSITY — PULLMAN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DAVIS, CHRISTOPHER JOHN — WASHINGTON STATE UNIVERSITY
- Study coordinator: DAVIS, CHRISTOPHER JOHN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.