Effects of partial sleep deprivation on heart function during cycling
Official title: Effects of Partial Sleep Deprivation on Cardiac Output During Cycling
Run by University of Guelph · NCT06679543 · Data updated 2026-11-12
This study is testing how not getting enough sleep affects heart function and blood pressure during cycling in young healthy adults, while also looking for differences between men and women.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 50 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | University of Guelph Academic / other |
| Locations | 1 site (Guelph, Ontario) |
| Status | Recruiting |
| Started | January 2, 2025 |
| Main results expected | December 2026 |
| Study ends | December 2026 |
| Registry record updated | April 28, 2026 |
| Trial ID | NCT06679543 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are young healthy adults aged 18-30, free from cardiovascular or metabolic diseases, and not currently taking chronic medications.
✕Probably not a fit
Patients with existing cardiovascular or metabolic diseases, sleep disorders, or those who are pregnant will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to investigate how partial sleep deprivation affects cardiac output and blood pressure during cycling exercise in young healthy adults, with a focus on potential sex differences. Participants will undergo testing after a night of normal sleep and after a night of reduced sleep, performing exercise on a cycle ergometer while their hemodynamics and plasma volume are monitored. The study seeks to understand whether reductions in plasma volume contribute to changes in cardiac output and blood pressure, particularly examining differences between males and females.
Why it matters
Potential benefit: If successful, this study could provide insights into how sleep deprivation impacts cardiovascular health during physical activity, potentially guiding recommendations for exercise in sleep-deprived individuals.
How similar studies have gone: While there is limited research specifically on the effects of partial sleep deprivation on cardiac output during exercise, related studies have shown significant impacts of sleep deprivation on cardiovascular responses, suggesting this approach may yield valuable insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Free of known cardiovascular or metabolic diseases or sleep disorders * No history of smoking (within the past 3 months) * Able to engage in physical activity assessed through the physical activity readiness questionnaire (PAR-Q+) * No prescription of chronic medications other than oral contraceptives * Able to abide by sleep protocols for all visits * Individuals who are not allergic to ultrasound gel * Individuals who are not pregnant Exclusion Criteria: * Individuals diagnosed with cardiovascular or metabolic disease or sleep disorders * Has a history of smoking (within the past 3 months) * Not ready to engage in physical activity as assessed by the PAR-Q+ * Individuals prescribed chronic medications other than oral contraceptives * Unable to abide by sleep protocols for any testing visit * Allergic to ultrasound gel * Pregnancy
Where it's running
-
University of Guelph
Guelph, Ontario, Canada Recruiting
Study contacts
- Principal investigator: Philip Millar, PhD — University of Guelph
- Study coordinator: Julian Bommarito, MSc
- Email: jbomma01@uoguelph.ca
- Phone: 9052209829
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Sleep and circadian care for ICU patients
This study tests a multicomponent sleep and circadian rhythm program in adult ICU patients to see if it helps keep daily rhythms and sleep better.
-
HBS-104 single doses in acutely sleep-deprived healthy adults
This study tests whether a single dose of HBS-104 is safe and how it behaves in the body when given to healthy adults who are acutely sleep-deprived.
-
Mind After Midnight — how being awake between 2:00 and 4:00 AM affects mood and decision-making
This project will test whether being awake during the biological night (2:00–4:00 AM) increases negative mood, poor decision-making, and suicidal thoughts in adults who have had suicidal ideation in the past six months.
-
Nighttime synchronization of eating and your circadian clock
This trial will test whether changing light exposure and when you eat during short sleep periods changes metabolism in healthy adults aged 18–35 who normally sleep 7–9 hours per night.
-
How the body clock affects time perception during 36 hours awake
This test will see if the internal body clock and staying awake for about 36 hours change how healthy adults experience and estimate time.
-
Effects of Sleep Loss and Alcohol on Brain and Performance in Healthy Adults
This study tests how sleep deprivation and moderate alcohol use affect thinking and motor skills in healthy adults to understand risks that could relate to spaceflight.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.