Condition

Relapse clinical trials and research

• 18Clinical trials
• 158NIH research projects
• 7Countries

Newest Relapse clinical trials

All recruiting trials (18)

• How facial type relates to relapse after orthodontic treatment during retention

  This study tests whether people with different facial types have different patterns of tooth movement relapse after orthodontic treatment during the retention phase.

  Recruiting Postgraduate Institute of Dental Sciences Rohtak · Rohtak, Haryana · NCT07622277

• Can a multi-omics and AI model predict ABPA relapse within 1 year in adults?

  This study tests a machine learning model that uses multi-omics and clinical data to predict the 1-year relapse risk for adults with ABPA who are in a stable state.

  Recruiting Qianfoshan Hospital · Jinan, Shandong · NCT07611838

• Serplulimab plus second-line chemo/targeted therapy for early-relapse colorectal cancer after adjuvant therapy

  This trial tests whether adding serplulimab to standard second-line chemotherapy plus targeted therapy helps people whose colorectal cancer came back early after adjuvant treatment.

  Recruiting Phase 2 Fudan University · Shanghai · NCT07604909

• How iNKT immune cells after allogeneic stem cell transplant relate to transplant complications

  This study tests whether levels of invariant NKT cells in the blood after an allogeneic stem cell transplant can be linked to complications like GvHD, infections, or relapse in patients with AML.

  Recruiting University Hospital Pilsen · Pilsen, Czechia · NCT07570407

• Daratumumab for refractory aplastic anemia in adults

  This trial tests whether daratumumab can be safely given and help people with refractory aplastic anemia see a benefit.

  Recruiting Phase 1/2 Institute of Hematology & Blood Diseases Hospital, China · Tianjin, Tianjin Municipality · NCT07287228

• Blinatumomab plus donor lymphocyte infusion to prevent relapse after transplant in high-risk Ph-negative B‑cell ALL

  This trial tests whether giving blinatumomab together with donor lymphocyte infusions can help prevent relapse in people aged 14–65 with high‑risk Philadelphia chromosome–negative B‑cell acute lymphoblastic leukemia after an allogeneic stem cell transplant.

  Recruiting Phase 2 First Affiliated Hospital of Zhejiang University · Hangzhou · NCT07105579

• Epcoritamab plus loncastuximab tesirine for relapsed or refractory large B-cell lymphoma

  This test gives epcoritamab together with loncastuximab tesirine to adults whose large B-cell lymphoma has come back or not responded, to see if it can shrink or clear the cancer.

  Recruiting Phase 2 University of Miami · Miami, Florida · NCT06919939

• Treatment of relapsed or refractory acute myeloid leukemia with a new drug combination

  This study is testing a new combination of drugs to see if it can help people with relapsed or refractory acute myeloid leukemia feel better and improve their treatment outcomes.

  Recruiting Phase 1 The First Affiliated Hospital of Xiamen University · Xiamen, Fujian · NCT06737523

• Preventing relapse in high-risk T-cell leukemia after stem cell transplant

  This study is testing if a new combination of medications can help prevent relapse in patients with high-risk T-cell leukemia after they have a stem cell transplant.

  Recruiting Phase 2 Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine · Shanghai · NCT06686108

• Motivational interviews to help maintain abstinence after alcohol withdrawal

  This study tests if using motivational interviews as extra support can help adults who have just gone through alcohol withdrawal stay sober longer compared to regular care.

  Recruiting University Hospital, Montpellier · Montpellier · NCT06618755

• Comparing two chemotherapy combinations for treating relapsed glioblastoma

  This study is testing two different chemotherapy combinations to see if they can help people with relapsed glioblastoma live longer and feel better.

  Recruiting Phase 2 Université de Sherbrooke · Sherbrooke, Quebec · NCT06356883

• Treatment using CAR-T cells targeting B7-H3 for triple-negative breast cancer

  This study is testing a new CAR-T cell treatment aimed at a specific target for people with hard-to-treat triple-negative breast cancer to see if it is safe and how much can be given.

  Recruiting Phase 1 UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT06347068

• Using CAR-T cells to target B7-H3 in pancreatic cancer

  This study is testing a new treatment using specially modified immune cells to see if they can safely help people with pancreatic cancer that has come back after other treatments.

  Recruiting Phase 1 UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT06158139

• Understanding stress responses in individuals with alcohol use disorder

  This study looks at how people with alcohol use disorder react to stress and whether these reactions affect their cravings and drinking habits over time.

  Recruiting at 2 sites Central Institute of Mental Health, Mannheim · Mannheim, Baden-Wurttemberg and 1 other locations · NCT06105853

• Using modified T cells to treat relapsed head and neck cancer

  This study is testing a new treatment using modified immune cells to see if it can help people with relapsed head and neck cancer feel better and improve their outcomes.

  Recruiting Phase 1 UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT06096038

• New cellular therapy for Hodgkin Lymphoma

  This study is testing a new type of cell therapy for people with relapsed or hard-to-treat Hodgkin Lymphoma to see if it is safe and effective.

  Recruiting Phase 1/2 UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT06090864

• Evaluating treatment approaches for Graves' disease management

  This study is testing different ways to use methimazole to treat Graves' disease and see how well they work in preventing the condition from coming back after stopping the medication for two years.

  Recruiting Phase 4 The First Affiliated Hospital with Nanjing Medical University · Nanjing · NCT05461820

• Intraarterial carboplatin combined with radiotherapy for relapsing glioblastoma

  This study is testing if a new way of giving carboplatin along with radiation can help people with relapsing glioblastoma live longer and feel better.

  Recruiting Phase 1/2 Université de Sherbrooke · Sherbrooke, Quebec · NCT03672721

NIH-funded research (newest 40 of 158)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Social stress and smoking: why disadvantaged young adults struggle to quit

  This grant looks at how daily social stress affects if and when disadvantaged young adults who smoke can quit and stay quit.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11540695

• Learning from remission and relapse in lupus (SLE)

  Researchers are studying people with systemic lupus erythematosus who are in long-term remission without steroids or immunosuppressants to understand their immune cells, brain function, and what might predict relapse.

  NIH research Feinstein Institute for Medical Research · Manhasset, United States · NIH-11513534

• Learning from Remission and Relapse in SLE

  A program to study people with systemic lupus erythematosus who are in long-term remission to understand immune and brain signals that might predict relapse.

  NIH research Feinstein Institute for Medical Research · Manhasset, United States · NIH-11513533

• Alternative NF-kB activation after chemotherapy in ovarian cancer

  This grant studies how ovarian cancer might come back after chemotherapy by looking at specific signaling pathways in cancer cells and the tumor environment.

  NIH research San Diego State University · San Diego, United States · NIH-11473227

• Predictors of autoimmunity onset and relapse in skin

  A study to understand what biological signals in skin predict when autoimmune diseases start, flare, or worsen in people at risk.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11471389

• Determinants of TB Control, Relapse, and Reinfection

  A large, multi-year study aims to understand why some people who are treated for TB still have persistent infection or relapse, with the goal of improving prevention and treatment.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11449646

• Metabolic drivers of B-ALL diversity and relapse risk

  A study at Stanford will explore how diverse B-cell receptor rearrangements and their metabolism shape relapse risk in children and adults with B-ALL, with the goal of improving detection and treatment.

  NIH research Stanford University · Stanford, United States · NIH-11434237

• Why lupus stays quiet for some people and flares for others

  Looking at immune cells and brain function in people with lupus who are in long-term remission without steroids or immunosuppressants to find markers linked to future relapse.

  NIH research Feinstein Institute for Medical Research · Manhasset, United States · NIH-11406909

• Understanding how chemotherapy-related changes fuel ovarian cancer relapse

  Aims to uncover how changes after chemotherapy help ovarian cancer come back and how to block those signals to help patients stay cancer-free.

  NIH research San Diego State University · San Diego, United States · NIH-11404912

• Fentanyl Overdose, Anhedonia, and Relapse Risk in Opioid Use Disorder

  This NIH grant aims to understand how a fentanyl overdose might cause anhedonia and raise the risk of relapse for people with opioid use disorder.

  NIH research Tufts University Boston · Boston, United States · NIH-11403998

• Donor CAR T Cells Added to Transplant to Prevent Relapse in adults with B-ALL

  A new approach combines donor CAR-T cells targeting CD19 and CD22 with a stem cell transplant to lower relapse risk in adults with B-ALL.

  NIH research Stanford University · Stanford, United States · NIH-11400088

• Promoting Breastfeeding to Prevent Postpartum Smoking Relapse

  A trial tests whether encouraging new mothers to breastfeed helps prevent them from starting to smoke again after giving birth.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11400074

• Helping people keep using preferred communication to reduce problem behaviors

  This project teaches people with intellectual and developmental disabilities to use preferred ways to communicate so they can get their needs met instead of using harmful behaviors like aggression or self-injury.

  NIH research University of Georgia · Athens, United States · NIH-11393756

• Mindfulness-Based Relapse Prevention via Video Calls for Long-Term Recovery from Alcohol Use Disorder

  A funded program tests video-delivered mindfulness-based relapse prevention to support adults with alcohol use disorder in achieving long-term recovery.

  NIH research University of New Mexico · Albuquerque, United States · NIH-11387731

• How a spouse's mental health and substance use may affect a partner's drinking problems

  A study looks at how a spouse’s psychiatric disorders and drinking habits influence when a person starts, stops, or relapses into alcohol use problems within marriage.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11383424

• Cognitive Processing Therapy plus Relapse Prevention for people with alcohol problems and PTSD

  This trial offers a combined Cognitive Processing Therapy and relapse-prevention program for adults with alcohol use disorder and PTSD to reduce drinking and PTSD symptoms.

  NIH research Texas A&m University · College Station, United States · NIH-11378367

• Real-time relapse risk scoring for Opioid Use Disorder from trial data

  A tool that uses data from opioid treatment trials to produce a real-time score predicting a patient’s risk of relapse in the near future.

  NIH research New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · New York, United States · NIH-11374999

• Adaptive treatment for early smoking relapse in adults

  This study tests different paths to help adults who smoke quit again after an early relapse, including trying a different quitting medicine or switching to a safer nicotine product.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11362332

• Molecular and clinical clues to relapse in ANCA-related vasculitis

  Researchers are studying nasal and airway signals, including bacteria and gene activity, to find predictors that a person with ANCA-associated vasculitis might relapse.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11361068

• Identifying epigenetic and brain-connectivity changes during opioid withdrawal and relapse

  Researchers are studying how opioid withdrawal and relapse affect the brain’s genes and wiring in rats using new cellular barcoding tools.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11360198

• CBT for Insomnia to Help Adults Who Smoke Quit and Sleep Better

  A sleep-focused therapy is tested to help adults who smoke sleep better, feel less negative, and improve their ability to quit smoking.

  NIH research Yale University · New Haven, United States · NIH-11353933

• Understanding why some MDS patients relapse after a stem cell transplant

  A study of patients with myelodysplastic syndromes after stem cell transplant to learn the cellular changes and gene activity that lead to relapse, with the goal of guiding future treatments.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11350441

• Targeting VLDLR to prevent both GvHD and leukemia relapse

  A new approach using the VLDLR target aims to prevent graft-versus-host disease while keeping the anti-leukemia effects after allogeneic stem cell transplantation.

  NIH research Washington University · Saint Louis, United States · NIH-11339890

• ZFP281 and early cancer spread: dormancy, local relapse, and distant metastasis

  Researchers are studying how a cancer gene called ZFP281 may control early cancer cell dormancy and later spread, with potential to inform better prevention of relapse.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-11335051

• Understanding how dormant breast cancer cells wake up and cause relapse

  A research team will look at how dormant cancer cells hide and later cause local or distant breast cancer relapse, with a goal to identify ways to prevent or treat it.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-11335049

• Smartphone app helps people on opioid treatment stay abstinent

  A smartphone app called OPTiMA supports people on medication-assisted treatment to stay in recovery by daily self-checks and personalized feedback.

  NIH research Univ of Arkansas for Med Scis · Little Rock, United States · NIH-11332430

• Circadian control of fentanyl craving: NPAS2 and D3 receptor in brain reward

  A scientist is studying how the body’s internal clock and a specific brain pathway influence fentanyl craving and relapse, with the goal of helping people with opioid use disorder.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11330600

• Long-term recovery from alcohol use — relapse, daily functioning, and brain-behavior markers

  This project follows people recovering from alcohol use disorder over many years to track relapse, everyday functioning, and brain-behavior signs.

  NIH research Virginia Polytechnic Inst and St Univ · Blacksburg, United States · NIH-11326693

• Personalized relapse risk tool for people with alcohol use disorder

  This project aims to build a personalized tool using brain and behavior data plus machine learning to predict relapse risk for adults with alcohol use disorder.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11326632

• B cells, cancer, and microbes: new ideas to understand relapse in B cell cancers

  A new NIH grant is exploring how usual gut bacteria and their signals might influence relapse and treatment resistance in B cell cancers, with potential to guide better therapies.

  NIH research Rutgers, the State Univ of N.j. · Piscataway, United States · NIH-11325848

• Clinical decision support to spot relapse risk early in teens with substance use disorders

  A new tool called LEVL helps clinicians spot early signs that a teen recovering from substance use might relapse, so they can intervene sooner.

  NIH research Pillsmart INC. · Brooklyn, United States · NIH-11316815

• Reducing leukemia relapse and graft-versus-host disease after donor stem-cell transplant by targeting CD83

  This work uses engineered immune cells that target a protein called CD83 to try to prevent relapse of acute leukemias and reduce graft-versus-host disease in people receiving donor stem-cell transplants.

  NIH research Roswell Park Cancer Institute Corp · Buffalo, United States · NIH-11311289

• Why nicotine cravings come back: the brain circuit behind relapse

  This project looks at a specific brain circuit that may cause strong nicotine cravings in people trying to quit smoking.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11307558

• How stress-related brain systems change alcohol drinking and relapse

  This research is testing whether two brain systems — the dynorphin/kappa opioid system and oxytocin — change how stress makes people with alcohol problems drink more and relapse.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11306585

• Changing the tumor environment to prevent relapse and lung spread in triple negative breast cancer

  This project gives a long‑term copper‑lowering medicine called tetrathiomolybdate to people with high‑risk triple negative breast cancer alongside standard chemotherapy and immunotherapy to help stop cancer from coming back.

  NIH research Dartmouth-Hitchcock Clinic · Lebanon, United States · NIH-11306075

• Biometric wearables to predict opioid relapse

  A brief study will test a wearable-based tool to forecast relapse risk in adults with opioid use disorder to help prevent overdose.

  NIH research Mclean Hospital · Belmont, United States · NIH-11302974

• Multimodal imaging to predict ulcerative colitis relapse

  A new imaging platform will be built to map tissue and immune signals in the gut to better predict when ulcerative colitis might flare again.

  NIH research University of Illinois at Urbana-Champaign · Champaign, United States · NIH-11302835

• Genes that make leukemia stem cells grow and cause AML to come back

  This project looks at which genes help leukemia stem cells survive treatment and cause AML to return in adults.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11300246

• How a stress-related brain circuit may drive opioid relapse in chronic pain

  This research looks at how a stress-related system in the amygdala may cause people with chronic pain to relapse on opioids.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11294304

• Online Helpers training to reduce smoking relapse by strengthening your support network

  An online program that teaches recent quitters to help friends or family stop smoking so their social circle becomes more supportive and they are less likely to relapse.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11286823

Related topics

Quick answers

How many Relapse clinical trials are recruiting right now?

18, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in China (7 trials), United States (5 trials), Canada (2 trials), France (1 trial), Czechia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 1: 4, Phase 1/2: 3, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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