NIH-funded research R01 grant

Long-term recovery from alcohol use — relapse, daily functioning, and brain-behavior markers

Official title: Longitudinal Study of Recovery: Psychosocial Functioning, Relapse, and Neuro-Behavioral Markers

Funded at Virginia Polytechnic Inst and St Univ · NIH-11326693 · Data updated 2026-11-12

This project follows people recovering from alcohol use disorder over many years to track relapse, everyday functioning, and brain-behavior signs.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionVirginia Polytechnic Inst and St Univ
NIH-funded
Lab location1 site (Blacksburg, United States)
Project startMarch 1, 2022
Project endFebruary 28, 2027
Funding year2026
Award (this year)$673,373
NIH project number5R01AA029135-05
Project IDNIH-11326693 on NIH RePORTER

Who could benefit from this research

Could help

Adults with a history of alcohol use disorder who are in recovery (including a range of recovery lengths) and who can join the online International Quit & Recovery Registry are ideal candidates.

Less likely to help

People without a history of problematic alcohol use or those unable or unwilling to participate in repeated online follow-up are unlikely to benefit directly from this project.

What this research studies

You would join an online registry of people who have quit or reduced drinking and complete regular surveys and computer-based tasks. The team enrolls people at different lengths of recovery so they can combine results to represent up to 12 years of recovery experience. The work looks at decision-making tied to impulsive versus control systems in the brain using computerized measures and repeated questionnaires. Most participation is remote through the International Quit & Recovery Registry with ongoing follow-up over time.

Why it matters

Potential benefit: If successful, this could reveal when and how relapse risk changes over the long term and point to better-timed or targeted relapse-prevention supports.

How similar studies have gone: Short-term studies have linked brain-behavior measures to relapse risk, but few projects have combined an accelerated longitudinal design and a large online recovery registry to map decade-long recovery trajectories, making this approach relatively novel.

Where this research is happening

  • Virginia Polytechnic Inst and St Univ
    Blacksburg, United States
    Active

Researchers

  • Principal investigator: Kim-Spoon, Jungmeen — Virginia Polytechnic Inst and St Univ
  • Study coordinator: Kim-Spoon, Jungmeen

Related research

Other NIH-funded projects on the same topics.

  • Social stress and smoking: why disadvantaged young adults struggle to quit

    This grant looks at how daily social stress affects if and when disadvantaged young adults who smoke can quit and stay quit.

    NIH research Medical University of South Carolina · Charleston, United States · NIH-11540695

  • Learning from remission and relapse in lupus (SLE)

    Researchers are studying people with systemic lupus erythematosus who are in long-term remission without steroids or immunosuppressants to understand their immune cells, brain function, and what might predict relapse.

    NIH research Feinstein Institute for Medical Research · Manhasset, United States · NIH-11513534

  • Learning from Remission and Relapse in SLE

    A program to study people with systemic lupus erythematosus who are in long-term remission to understand immune and brain signals that might predict relapse.

    NIH research Feinstein Institute for Medical Research · Manhasset, United States · NIH-11513533

  • Alternative NF-kB activation after chemotherapy in ovarian cancer

    This grant studies how ovarian cancer might come back after chemotherapy by looking at specific signaling pathways in cancer cells and the tumor environment.

    NIH research San Diego State University · San Diego, United States · NIH-11473227

  • Predictors of autoimmunity onset and relapse in skin

    A study to understand what biological signals in skin predict when autoimmune diseases start, flare, or worsen in people at risk.

    NIH research Massachusetts General Hospital · Boston, United States · NIH-11471389

  • Determinants of TB Control, Relapse, and Reinfection

    A large, multi-year study aims to understand why some people who are treated for TB still have persistent infection or relapse, with the goal of improving prevention and treatment.

    NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11449646

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.