Molecular and clinical clues to relapse in ANCA-related vasculitis
Official title: Molecular and clinical predictors of relapse in ANCA-associated vasculitis
Funded at University of Pennsylvania · NIH-11361068 · Data updated 2026-11-12
Researchers are studying nasal and airway signals, including bacteria and gene activity, to find predictors that a person with ANCA-associated vasculitis might relapse.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 18, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $482,934 |
| NIH project number | 5R01AR084646-03 |
| Project ID | NIH-11361068 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with ANCA-associated vasculitis who are currently in clinical remission and under care at participating centers.
✕Less likely to help
Patients without relapse risk factors or without airway involvement may see limited benefit.
What this research studies
This project looks at people with ANCA-associated vasculitis to see if nasal tissue biology and symptoms can forecast relapse months before it happens. It uses 16S sequencing to profile airway microbes and gene expression, plus patient-reported outcomes to identify early warning signs. The goal is to find biomarkers that could guide personalized treatment decisions and potentially reduce unnecessary continued immunosuppression. If successful, patients in remission could receive earlier or tailored therapies to prevent flares.
Why it matters
Potential benefit: If the biomarkers are accurate, patients could avoid relapses or experience earlier, more targeted treatment adjustments.
How similar studies have gone: Preliminary data suggest nasal gene expression and microbial changes may precede relapse, but this approach needs validation in larger groups.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Rhee, Rennie — University of Pennsylvania
- Study coordinator: Rhee, Rennie
Related research
Other NIH-funded projects on the same topics.
-
Understanding ANCA-Associated Vasculitis Relapse from Upper Airway Changes
This project aims to find early signs in the nose that can tell us when ANCA-associated vasculitis (AAV) might come back, helping doctors better manage the disease.
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Investigating predictors of relapse in ANCA-associated vasculitis
This study is looking at how certain genes and bacteria in the nose can help predict when people with ANCA-associated vasculitis might have a relapse, even if they aren't showing any symptoms, so doctors can better adjust their treatments and manage the condition.
-
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This study is looking at how a protein called alpha-1 antitrypsin influences immune cells in people with ANCA-associated vasculitis, a rare autoimmune disease, to help find better ways to treat and predict flare-ups for those affected.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.