Condition

Refractory clinical trials and research

• 9Clinical trials
• 5Countries

Newest Refractory clinical trials

All recruiting trials (9)

• Intratumoral DNX-2401 for High-Grade Pediatric Brain Tumors

  This study tests whether a single injection of DNX-2401 into a pediatric brain tumor can help shrink the tumor and extend survival in kids and young adults with recurrent or refractory high-grade brain tumors.

  Recruiting Phase 2 Clinica Universidad de Navarra, Universidad de Navarra · Utrecht and 1 other locations · NCT07424092

• Micropulse laser treatment for new and refractory center-involved diabetic macular edema

  This project will test whether a subthreshold 577 nm micropulse laser helps adults with new or treatment-resistant center-involved diabetic macular edema reduce retinal swelling and improve vision.

  Recruiting The General Authority for Teaching Hospitals and Institutes · Cairo · NCT07295704

• Daratumumab for refractory aplastic anemia in adults

  This trial tests whether daratumumab can be safely given and help people with refractory aplastic anemia see a benefit.

  Recruiting Phase 1/2 Institute of Hematology & Blood Diseases Hospital, China · Tianjin, Tianjin Municipality · NCT07287228

• xDRIVE personalized tumor testing for Florida cancer patients

  This program will try a functional precision medicine and AI platform (xDRIVE) to help guide next treatment options for Florida patients with recurrent or refractory cancer, including children and people from underserved communities.

  Recruiting First Ascent Biomedical Inc. · Miami, Florida and 1 other locations · NCT07167381

• CD19-targeted CAR-T (MC-1-50) for adults with refractory SLE

  This trial will try a rapid-manufactured CD19-directed CAR-T cell therapy called MC-1-50 in adults whose SLE has not responded to standard treatments.

  Recruiting at 2 sites Phase 1 Chongqing Precision Biotech Co., Ltd · Hefei, Anhui and 1 other locations · NCT06892145

• Testing a new CAR-T therapy for multiple myeloma

  This study is testing a new CAR-T therapy for people with hard-to-treat multiple myeloma to see how safe it is and what the best dose is.

  Recruiting Early Phase 1 Shanghai Cell Therapy Group Co.,Ltd · Shanghai · NCT06732232

• New treatment for children with hard-to-treat retinoblastoma

  This study is testing a new drug for children with hard-to-treat eye cancer to see if it works better and has fewer side effects than standard chemotherapy.

  Recruiting Early Phase 1 Eye & ENT Hospital of Fudan University · Shanghai · NCT06424301

• Exploring new treatment options for refractory or relapsed acute myeloid leukemia

  This study is testing different treatment options for people with stubborn or returning acute myeloid leukemia to see which ones work best for them.

  Recruiting Institute of Hematology & Blood Diseases Hospital, China · Tianjin · NCT06265545

• New cellular therapy for Hodgkin Lymphoma

  This study is testing a new type of cell therapy for people with relapsed or hard-to-treat Hodgkin Lymphoma to see if it is safe and effective.

  Recruiting Phase 1/2 UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT06090864

Related topics

Quick answers

How many Refractory clinical trials are recruiting right now?

9, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in China (5 trials), United States (2 trials), Egypt (1 trial), Netherlands (1 trial), Spain (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 2, Early Phase 1: 2, Phase 1: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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