Learning from Remission and Relapse in SLE
Funded at Feinstein Institute for Medical Research · NIH-11513533 · Data updated 2026-11-12
A program to study people with systemic lupus erythematosus who are in long-term remission to understand immune and brain signals that might predict relapse.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project start | May 9, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $132,967 |
| NIH project number | 3P01AI172523-03S1 |
| Project ID | NIH-11513533 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with systemic lupus erythematosus who are in long-term remission without corticosteroids or immunosuppressants.
✕Less likely to help
Patients not meeting remission criteria or those with active disease are less likely to benefit.
What this research studies
We will analyze blood immune cells at the single-cell level to map immune cell types, epigenetic marks, and protein profiles. We will examine B cell repertoires to see which cells react to nuclear antigens. We will also explore brain function in these patients to look for hidden inflammation and to link immune profiles with brain activity. By following patients over several years, we aim to identify predictors of relapse and understand why some stay in remission while others flare.
Why it matters
Potential benefit: If successful, the findings could help predict relapse and guide personalized monitoring or early interventions for people with SLE.
How similar studies have gone: Similar single-cell and brain-imaging approaches have provided meaningful insights in autoimmune diseases, though this exact remission-relapse focus is relatively novel.
Where this research is happening
-
Feinstein Institute for Medical Research
Manhasset, United States Active
Researchers
- Principal investigator: Diamond, Betty — Feinstein Institute for Medical Research
- Study coordinator: Diamond, Betty
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.