Determinants of TB Control, Relapse, and Reinfection
Funded at Weill Medical Coll of Cornell Univ · NIH-11449646 · Data updated 2026-11-12
A large, multi-year study aims to understand why some people who are treated for TB still have persistent infection or relapse, with the goal of improving prevention and treatment.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $2,217,926 |
| NIH project number | 2P01AI202868-06 |
| Project ID | NIH-11449646 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with a history of TB treatment or latent infection who are at risk for paucibacillary TB and related persistent states.
✕Less likely to help
People without TB or those outside the studied populations may not directly benefit.
What this research studies
This program-supported effort investigates why Mycobacterium tuberculosis can persist after treatment and cause relapse or reinfection. It combines three integrated projects and two scientific cores to study host and bacterial factors in paucibacillary TB, using human data, patient cohorts, and animal models to identify markers and mechanisms. The research will build on previous findings about microbiomic markers of treatment failure and host immune factors, including autoantibodies, to better predict outcomes and guide new therapies. By uncovering drivers of LTBI and PTPI, the team hopes to inform strategies that prevent relapse and reduce transmission. The work is conducted at Weill Cornell in New York, led by Sabine Ehrt and colleagues with a focus on translating discoveries into better patient care.
Why it matters
Potential benefit: If successful, the project could lead to better prediction of relapse risk and new approaches to prevent reactivation and relapse in TB patients.
How similar studies have gone: Previous work has identified microbiomic markers and host factors; this program extends those findings in a larger, integrated framework.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Ehrt, Sabine — Weill Medical Coll of Cornell Univ
- Study coordinator: Ehrt, Sabine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.