Targeting VLDLR to prevent both GvHD and leukemia relapse

Who could benefit from this research

What this research studies

This project explores a way to separate the good graft-versus-leukemia effect from the harmful graft-versus-host disease in people who receive donor stem cell transplants. Using a genome-wide CRISPR screen, researchers identified VLDLR as a potential target to block GvHD without losing GvL. The work combines animal studies and human data to test how blocking VLDLR affects T cells and transplant outcomes. If successful, this could lead to therapies that reduce transplant complications and improve relapse control.

Why it matters

Where this research is happening

• Washington University
  Saint Louis, United States Active

Researchers

• Principal investigator: Choi, Jaebok — Washington University
• Study coordinator: Choi, Jaebok

Related research

Other NIH-funded projects on the same topics.

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• Targeting a specific protein to prevent leukemia relapse and complications after stem cell transplants

  This study is looking at a new way to help patients with leukemia who are getting a stem cell transplant by using special T cells that target a protein called CD83, which could help prevent the cancer from coming back and reduce side effects from the transplant.

  NIH research Roswell Park Cancer Institute Corp · Buffalo, United States · NIH-10812513

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.