Condition

Alzheimer's Disease (AD) clinical trials and research

• 16Clinical trials
• 24NIH research projects
• 2New in 30 days
• 8Countries

Newest Alzheimer's Disease (AD) clinical trials

All recruiting trials (16)

• Effectiveness and Safety of Disease-Modifying Therapy for Alzheimer's Disease in Real World Practice

  This study will look at real-world safety and effectiveness of disease-modifying therapy (DMT) in adults with MCI or Alzheimer's dementia by comparing those who receive DMT in routine care to those who do not.

  Recruiting Fudan University · Shanghai, Jingan · NCT07923812

• Automated language analysis to help diagnose neurodegenerative diseases

  A multilingual AI-powered language test is being tried to see if speech and language patterns can help differentiate Alzheimer’s, frontotemporal dementia, Lewy body dementia, and Parkinson’s from healthy aging.

  Recruiting Istituti Clinici Scientifici Maugeri SpA · Bari · NCT07906769

• LIFU to Help Sleep and Amyloid Reduction in Older Adults with Cognitive Impairment

  A wearable ultrasound device (ATTN201) is being tested to see if it’s safe and easy to use for people 65 and older with mild cognitive impairment and amyloid buildup.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07866768

• Urolithin A for early Alzheimer’s disease: a test with a nutritional supplement

  This trial tests whether taking urolithin A in addition to standard care helps people with early Alzheimer’s or mild cognitive impairment show better biomarkers and cognition.

  Recruiting University Hospital, Akershus · Prague · NCT07842146

• Longitudinal profiling of plasma-derived glial extracellular vesicles in Alzheimer's disease

  This study tests whether plasma glial extracellular vesicles and neuroinflammation biomarkers change over time across the Alzheimer’s disease spectrum and whether these signals relate to amyloid, tau, and neurodegeneration, with an additional step of exposing healthy iPSC-derived neurons to vesicles to see potential ne

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Rome · NCT07803055

• Biomarker Repository for Age-Related and Inherited Neurodegenerative Diseases

  This study collects blood and genetic samples from people with neurodegenerative diseases and their families to build a shared resource for studying disease risk and biology.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT07798700

• See if blood tests for AD biomarkers help diagnose Alzheimer’s earlier and more accurately

  This trial tests whether blood-based biomarkers for Alzheimer's disease can help memory clinics diagnose AD more accurately and quickly for patients with cognitive concerns.

  Recruiting at 7 sites Alzheimercentrum Amsterdam · Amsterdam, North Holland and 7 other locations · NCT07680335

• Blood-based biomarkers for Alzheimer’s disease in primary care

  This study tests whether a blood test for ps-tau217 and the ps-tau217/Aβ42 ratio can help primary care patients with cognitive concerns understand their situation.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT07666113

• Early detection program for subtle memory and thinking changes in older adults

  This project will test a targeted cognitive screening program to find early memory and thinking problems in people aged 60 and older who notice changes.

  Recruiting Ludwig-Maximilians - University of Munich · München · NCT07466394

• Measuring Hsp90 levels in the human brain

  This trial tests whether a PET tracer called [11C]HSP990 can measure Hsp90 levels in the brains of healthy adults and people with Parkinson's disease, Alzheimer's disease, or ALS.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven, Vlaam-Brabant · NCT07380204

• Neuropsychological tool to measure how people with Alzheimer's perceive and think about time

  This project tests the Chronos battery to measure different aspects of time perception and time-related memory in people with Alzheimer's disease who have episodic memory and other cognitive deficits.

  Recruiting University Hospital, Caen · Caen · NCT07341009

• Imaging demyelination with [18F]3F4AP PET

  This test uses a PET tracer called [18F]3F4AP in adults with demyelinating conditions and in healthy volunteers to see how the tracer moves through the body.

  Recruiting Phase 1 Yale University · New Haven, Connecticut · NCT06999434

• Using a new PET tracer to measure TDP-43 protein in dementia and ALS

  This study is testing a new imaging method to see if it can safely detect a specific protein linked to frontotemporal dementia and ALS in the brains of people with these conditions and healthy volunteers.

  Recruiting Early Phase 1 AC Immune SA · Amsterdam · NCT06891716

• Improving dementia treatment assessment methods

  This study is testing a new way to see if donepezil can help people with dementia feel better by looking at their thinking skills and daily activities, while also checking if certain markers in the body play a role in how well the treatment works.

  Recruiting The University of Texas Health Science Center at San Antonio · San Antonio, Texas · NCT05592678

• Validation of a new test for social-cognitive functioning

  The REALSoCog game-like test will be tried to see if it detects social-cognitive problems in people with Alzheimer's disease, Lewy body dementia, or frontotemporal degeneration.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT05558709

• Examining how the brain clears amyloid-β in Alzheimer's disease

  This study is trying to understand how the brain gets rid of a harmful protein in people with early signs of Alzheimer's disease to help find better treatments in the future.

  Recruiting Ludwig-Maximilians - University of Munich · München, Bavaria · NCT05059158

NIH-funded research (24)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Alzheimer’s disease and related brain changes linked to chemicals in the body

  This NIH grant supports a patient-centered effort to map how environmental exposures and body chemistry relate to Alzheimer’s disease and related dementias.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11609306

• Understanding how everyday exposures affect Alzheimer's disease progression

  A national research effort is studying how environmental exposures, gut health, diet, and metabolism relate to Alzheimer's and related dementias to identify new ways to diagnose and treat these conditions.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11609305

• How environment, gut health, and metabolism affect Alzheimer’s disease

  This grant looks at how environmental exposures, gut microbes, diet, and metabolism influence Alzheimer’s disease and related dementias.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11609304

• Understanding how chemical exposures affect Alzheimer's disease progression

  This project studies how environmental chemicals and other biological factors influence brain health and the course of Alzheimer’s disease and related dementias.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11605998

• Understanding how brain hyperexcitability and sex differences affect Alzheimer’s disease

  This grant tests whether brain hyperexcitability linked to a genetic risk (APOE4) and sex differences contribute to memory decline in Alzheimer’s disease, using computer simulations and mouse data to guide potential human treatments.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11537709

• CNS Exosomes and Adaptive Immunity in Alzheimer’s Disease

  This project studies how tiny brain vesicles called exosomes may activate the body's immune system in Alzheimer’s disease, with the goal of understanding mechanisms that could lead to new treatments.

  NIH research Tufts University Boston · Boston, United States · NIH-11380705

• How everyday chemical exposures may affect Alzheimer's disease and its course

  Researchers will analyze blood, gut, genetic, and brain imaging data from people with and without Alzheimer's to find chemical and metabolic patterns tied to the disease.

  NIH research Duke University · Durham, United States · NIH-11379382

• How everyday chemical exposures may change Alzheimer's and its course

  This project looks at how chemicals in the environment, diet, and the gut interact with genes and blood chemistry to relate to Alzheimer's for people with or at risk for the disease.

  NIH research Duke University · Durham, United States · NIH-11379381

• Protective Relin Variant in Alzheimer’s Preventive Research

  This NIH grant explores how a rare genetic variant may protect against Alzheimer’s disease and what this could mean for preventing dementia in people at risk.

  NIH research Arizona State University-Tempe Campus · Scottsdale, United States · NIH-11356906

• Can nilotinib reverse high‑fat diet–related brain changes in Alzheimer's and do males and females respond differently?

  This work looks at whether the leukemia drug nilotinib can improve brain energy, memory, and Alzheimer’s brain changes caused by a high‑fat diet, and whether effects differ for males and females.

  NIH research Nova Southeastern University · Fort Lauderdale-Davie, UNITED STATES · NIH-11324282

• RNAi-based approach to modify ApoE, immune signals, and tau for a potential Alzheimer’s treatment

  A gene-silencing strategy in the brain aims to slow or alter Alzheimer’s disease by targeting ApoE, immune signals, and tau together.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11300816

• Brain overactivity and sex differences in Alzheimer's linked to APOE-ε4

  Researchers are looking at whether the anti-seizure drug levetiracetam can calm brain overactivity and help memory in people at risk for Alzheimer's because of the APOE-ε4 gene, with a focus on women.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11187233

• Chemical exposures and Alzheimer's progression

  This project looks at how everyday chemical exposures, the gut microbiome, genes, and blood metabolites relate to Alzheimer's disease in people with or at risk for dementia.

  NIH research Duke University · Durham, United States · NIH-11170671

• Smart cell delivery to target and control combination treatments for Alzheimer's

  A team is developing a living cell system to carry and release combinations of Alzheimer's medicines directly where they're needed for people with Alzheimer's disease.

  NIH research Buck Institute for Research on Aging · Novato, United States · NIH-11126840

• How tiny particles from brain cells may trigger the immune system in Alzheimer’s

  This project looks at whether small vesicles released by brain cells carry Alzheimer’s-related signals that activate the immune system in people with Alzheimer’s disease.

  NIH research Tufts University Boston · Boston, United States · NIH-11103395

• Understanding how aging affects brain function in Alzheimer's disease

  This study is looking at how the aging process affects brain health and could lead to problems like Alzheimer's disease, with the hope of finding new ways to help people with these conditions.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11098517

• Investigating how a high fat diet affects Alzheimer's disease differently in men and women and if nilotinib can help.

  This study is looking at how a high-fat diet affects Alzheimer's disease differently in men and women, and it will test if a leukemia drug called nilotinib can help improve brain health and memory in mice that are on this diet.

  NIH research Nova Southeastern University · Fort Lauderdale-Davie, UNITED STATES · NIH-11061864

• New treatments for Alzheimer's Disease using protein activators

  This study is looking at new pills that could help fight Alzheimer's Disease by boosting a protein that may help reduce brain inflammation and other issues related to the condition, and it's testing how well these pills work in different models.

  NIH research Atux Iskay Group LLC · Plainsboro, United States · NIH-11041145

• Investigating the link between insulin resistance and Alzheimer's disease

  This study is looking at how problems with insulin in the brain might be linked to Alzheimer's disease and aims to find new ways to help improve thinking and memory for people dealing with this condition.

  NIH research Regene LLC · Belchertown, UNITED STATES · NIH-11014382

• Investigating how chemical exposures affect Alzheimer's disease and its progression

  This study is looking at how things like your environment, genes, diet, and lifestyle affect brain health, especially in relation to Alzheimer's disease, and it invites patients to help researchers understand how their unique body chemistry connects to their thinking and memory.

  NIH research Duke University · Durham, United States · NIH-10973577

• Exploring how brain activity differences between sexes affect Alzheimer's disease.

  This study is looking at how differences in brain activity might affect Alzheimer's disease, especially in women with a specific gene, and it’s testing whether a common seizure medication can help improve thinking skills in both people and mice.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-10932678

• A new method to deliver drugs for Alzheimer's disease treatment.

  This study is exploring a new way to deliver medications for Alzheimer's disease that could make treatments work better by targeting different aspects of the condition, so patients might have a more effective option for managing their symptoms.

  NIH research Buck Institute for Research on Aging · Novato, United States · NIH-10873903

• Developing a new organoid tool to study and treat Alzheimer's disease.

  This study is working on a special toolkit that uses tiny brain-like structures to help us learn more about Alzheimer's disease and find new treatments, which could ultimately help patients like you.

  NIH research Sxrna Technologies, INC. · Albany, United States · NIH-10765970

• Using AI to create personalized treatments for Alzheimer's Disease

  This study is working on a smart app that will help doctors create personalized treatment plans for people with Alzheimer's Disease who also have other health issues like heart problems, diabetes, or depression, by looking at how different medications affect their thinking skills.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10701069

Related topics

Quick answers

How many Alzheimer's Disease (AD) clinical trials are recruiting right now?

16, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (4 trials), Belgium (2 trials), Italy (2 trials), Germany (2 trials), France (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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