Acupuncture and Moxibustion for Motor Symptoms in Early Parkinson's Disease
Effect of "Qi-Tonifying, Yang-Warming, and Water-Resolving" Acupuncture and Moxibustion for Motor Symptom Improvement in Early Parkinson's Disease (WARMED): A Randomized Controlled Trial
This study is testing a special acupuncture method to see if it can help improve movement problems in people with early Parkinson's Disease.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 30 Years to 80 Years |
| Sex | All |
| Sponsor | Guang'anmen Hospital of China Academy of Chinese Medical Sciences Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT06874803 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness and safety of a specific acupuncture method, termed 'Qi-Tonifying, Yang-Warming, and Water-Resolving', in improving motor symptoms in patients with early Parkinson's Disease. It employs a randomized, triple-blind, controlled design with 90 participants, comparing the acupuncture treatment to a sham procedure. The study will assess changes in motor function using the UPDRS scores and explore the underlying mechanisms through functional MRI. The trial aims to provide insights into the clinical benefits of acupuncture for this condition.
Who should consider this trial
Good fit: Ideal candidates are adults aged 30 to 80 diagnosed with mild to moderate Parkinson's Disease.
Not a fit: Patients with Parkinson-plus syndromes or severe systemic organ dysfunction may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could offer a non-invasive treatment option to improve motor symptoms in early Parkinson's Disease patients.
How similar studies have performed: Other studies have shown promising results with acupuncture for Parkinson's Disease, suggesting potential efficacy for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Participants must meet all of the following criteria: 1\. Diagnosed with Parkinson's disease (PD) according to the 2016 Chinese 2. Diagnostic Criteria for Parkinson's Disease. 3\. Hoehn-Yahr stage \<3 (mild to moderate PD). 4. Age between 30 and 80 years (inclusive). 5. Signed informed consent indicating voluntary participation. Exclusion Criteria: Participants meeting any of the following criteria will be excluded: 1. Diagnosed with Parkinson-plus syndromes or other secondary parkinsonism. 2. Prior history of deep brain stimulation (DBS) surgery. 3. Severe cerebrovascular disease, brain trauma, or history of craniotomy. 4. Severe dementia or psychiatric disorders that prevent cooperation with study procedures. 5. Severe coagulation disorders. 6. Presence of severe systemic organ dysfunction (cardiac, pulmonary, hepatic, renal, endocrine, or metabolic disorders). 7. Pregnant or breastfeeding women. 8. History of allergic reaction to acupuncture or moxibustion. 9. Prior treatment with acupuncture or moxibustion within the past three months. 10. Participation in another clinical trial within the past three months.
Where this trial is running
Beijing, Beijing Municipality
- Guang'anmen Hospita, China Academy of Chinese Medical Sciences — Beijing, Beijing Municipality, China (Recruiting)
Study contacts
- Study coordinator: Yu Liu, MD
- Email: yliu133@mgh.harvard.edu
- Phone: 8572650199
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.