Using subcortical brain signals to guide DBS contact selection for Parkinson's
Assessing the Relation Between Subcortical LFPs and DBS Parameter Selection in Parkinson's Disease - a Prospective Study
University Hospital of Leuven Leuven · NCT07485621
It will test whether local field potential (LFP) recordings can help pick the best deep brain stimulation contact for people with Parkinson's disease during routine hospital visits.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital of Leuven Leuven (other) |
| Locations | 1 site (Leuven, Vlaams-Brabant) |
| Trial ID | NCT07485621 on ClinicalTrials.gov |
What this trial studies
This observational project collects subcortical local field potential (LFP) recordings that are already part of routine clinical care to see if signal patterns align with clinically optimized DBS contact choices. No experimental interventions are added; data are compared to the contacts chosen through standard clinical programming. The aim is to determine whether an LFP-informed rule could reproduce or predict the contact selected after clinical optimization. Participants are adults with idiopathic Parkinson's disease who are eligible for DBS and able to communicate in Dutch or French at University Hospitals Leuven.
Who should consider this trial
Good fit: Adults (18+) with idiopathic Parkinson's disease who have been judged eligible for DBS and who understand Dutch or French are the intended participants.
Not a fit: People who are not DBS candidates, have atypical parkinsonism, or cannot participate in Dutch or French are unlikely to benefit from the LFP-based approach tested here.
Why it matters
Potential benefit: If successful, LFP-guided contact selection could shorten programming time and help personalize DBS settings to improve symptom control.
How similar studies have performed: Previous exploratory work has shown promising correlations between subcortical LFP features (for example beta-band activity) and optimal DBS parameters, but large confirmatory studies are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Voluntary written informed consent of the participant 2. At least 18 years of age at the time of signing the Informed Consent Form (ICF) 3. Diagnosis of idiopathic Parkinson's disease according to the clinical diagnostic criteria of the Movement Disorder Society (MDS) 4. Eligible for DBS to treat refractory PD motor symptoms, as based on multidisciplinary DBS screening 5. Have sufficient understanding of the Dutch and French language to participate in the study Exclusion Criteria: * /
Where this trial is running
Leuven, Vlaams-Brabant
- University Hospitals Leuven — Leuven, Vlaams-Brabant, Belgium (RECRUITING)
Study contacts
- Study coordinator: Bart Swinnen, MD, PhD
- Email: bart.swinnen@uzleuven.be
- Phone: 0032 16343044
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Parkinson's Disease, Deep brain stimulation, Local field potentials, Parkinson's disease