Early PD signals in people with REM sleep behavior disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to deeply characterize early-stage Parkinson’s disease in individuals with REM sleep behavior disorder using multimodal assessments. Participants may undergo advanced imaging and noninvasive evaluations to identify biomarkers and non-motor symptoms that precede motor PD. The research team includes the Danish Research Centre for Magnetic Resonance and collaborators at Danish Sleep Medicine centers, with a focus on understanding prodromal PD trajectories. Enrollment includes adults with verified RBD and age-matched healthy controls, who can provide informed consent. The goal is to improve early detection and inform future interventions for synucleinopathies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Both groups - The ability to give informed consent

For RBD-group

* Verified REM-sleep behaviour disorder via polysonography
* No other significant neurological and psychiatric ilness

For Healthy controls

\- Age matched to RBD-group

Exclusion Criteria:

* Ferrous objects in or around the body
* Pacemaker or other implanted electronic devices
* Drug abuse unrelated to medication or alcohol abuse over a period of 6 months prior to the experiment
* Other major immunological, cardiac, neurological or neuropsychiatric disorders
* Claustrophobia
* Incapability of giving informed consent
* Unwillingness to be informed about abnormal findings.
* Participation in clinical trials involving drug testing over a period of 6 months prior to the experiment.
* Disease symptoms leading to excessive movement inside the scanner (e.g., excessive tremor)

Where it's running

• Danish Research Centre for Magnetic Resonance
  Hvidovre, Denmark Recruiting

Study contacts

• Study coordinator: Sune G Thomsen, MD
• Email: sune.gram.thomsen.01@regionh.dk
• Phone: +4552176251

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.