Brain-signal guided DBS programming for Parkinson's
Official title: Electrophysiology-based Deep Brain Stimulation Programming for Parkinson's Disease
Run by University of Florida · NCT07348705 · Data updated 2026-11-12
This study will test whether using brain signals recorded from your Percept DBS device (beta power or a broad-band algorithm) can pick stimulation settings that work as well or better than standard clinician programming for people with Parkinson's.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 21 Years to 89 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | University of Florida Academic / other |
| Locations | 1 site (Gainesville, Florida) |
| Status | Recruiting |
| Started | January 15, 2026 |
| Main results expected | January 15, 2027 |
| Study ends | January 15, 2031 |
| Registry record updated | March 30, 2026 |
| Trial ID | NCT07348705 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 21–89 with idiopathic Parkinson's disease who have a Medtronic Percept DBS implant, can give informed consent, and are willing to participate at the initial programming visit.
✕Probably not a fit
Patients without a Percept-compatible implant, those with atypical parkinsonism, or those unable to comply with study procedures or whose mood/personality would interfere are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Up to 30 people with Parkinson's who already have a Medtronic Percept bidirectional DBS implant will have local field potentials (LFPs) recorded while their device is functioning. Physicians will perform the usual clinician-guided monopolar review without seeing the physiology data, and the LFP recordings will be analyzed separately to identify contacts based on maximum beta power and a novel broad-band algorithm. Up to four stimulation programs will be created: clinician-based, maximum-beta-based, broad-band algorithm-based, and an optional second clinician program, and these settings will be compared. The broad-band program is derived by a novel electrophysiology algorithm, though its resulting parameters may sometimes match conventional settings.
Why it matters
Potential benefit: If successful, this approach could make DBS programming faster and more objective and might improve symptom control by selecting stimulation contacts guided by brain signals.
How similar studies have gone: Previous work has shown that beta-band LFP signals correlate with motor symptoms and can inform programming in small studies, but broad-band algorithmic programming remains relatively novel and not yet validated in large trials.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with a diagnosis of idiopathic PD fulfilling the Movement Disorder Society Clinical Diagnostic Criteria for PD * DBS implantation with the Percept DBS device (Medtronic, USA) for the treatment of motor symptoms * Ability to give informed consent for the study * Willingness to do this study at the time of the initial programming session * Age 21 to 89 years old Exclusion Criteria: * Inability to comply with the study protocol * Atypical Parkinsonism * Any personality or mood symptoms that study personnel believe will interfere with the study requirements
Where it's running
-
Norman Fixel Institute for Neurological Diseases
Gainesville, Florida, United States Recruiting
Study contacts
- Principal investigator: Joshua Wong, MD — University of Florida
- Study coordinator: Joshua Wong, MD
- Email: Joshua.Wong@neurology.ufl.edu
- Phone: 352-294-5400
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.