Comparing effects of carotid artery procedures on brain function and blood flow
Change of Hemodynamics and Cerebral Functions After Carotid Artery Revascularization
This study looks at how two different surgeries for blocked carotid arteries affect blood flow and thinking skills in patients over time.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | Beijing Friendship Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT05539781 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the long-term effects of carotid artery revascularization procedures, specifically carotid endarterectomy (CEA) and carotid artery stenting (CAS), on hemodynamics and cognitive function in patients with significant carotid artery stenosis. The researchers will analyze how changes in blood flow and arterial structure post-surgery relate to cognitive outcomes and the risk of complications such as restenosis. By combining clinical data with advanced imaging and computational modeling, the study seeks to establish new prognostic factors for patient outcomes following these interventions.
Who should consider this trial
Good fit: Ideal candidates include patients with symptomatic carotid artery stenosis of 70% or greater and asymptomatic stenosis of 80% or greater who can provide informed consent.
Not a fit: Patients with previous disabling strokes, significant contralateral carotid occlusion, or systemic diseases incompatible with the procedures may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding of how carotid artery procedures affect cognitive function and help optimize treatment strategies for patients at risk of stroke.
How similar studies have performed: While there have been studies on carotid artery interventions, this specific approach combining hemodynamic analysis and cognitive assessment is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Informed consent signed Patients with \>=70% symptomatic or \>=80% asymptomatic internal carotid stenosis Exclusion Criteria: Incapability to give informed consent Previous disabling stroke Contralateral carotid occlusion or \>70% stenosis Systemic disease judged non compatible with the procedures or randomization Suspected or manifested pregnancy General contraindications to MRI or CT studies
Where this trial is running
Beijing, Beijing Municipality
- Beijing Friendship Hospital, Capital Medical University — Beijing, Beijing Municipality, China (Recruiting)
Study contacts
- Study coordinator: Mingyuan Liu, PhD
- Email: dr.mingyuanliu@pku.edu.cn
- Phone: +8613011157272
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.