Exploring tiny RNAs as potential markers for brain diseases linked to gammaherpesvirus.
Official title: Tiny RNAs as new potential biomarkers for gammaherpesvirus-driven neurological and central nervous system diseases
Funded at Ohio State University · NIH-10839906 · Data updated 2026-11-12
This study is looking at tiny pieces of genetic material linked to the Epstein-Barr virus to see if they can help doctors diagnose brain-related issues in people with weakened immune systems, and patients may be asked to share samples to help with this research.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | May 10, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $192,590 |
| NIH project number | 5R21AI178624-02 |
| Project ID | NIH-10839906 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children and young individuals aged 0-21 who are immunocompromised or have neurological symptoms potentially linked to EBV.
✕Less likely to help
Patients who are not affected by EBV or do not exhibit neurological symptoms may not benefit from this research.
What this research studies
This research investigates the role of tiny RNAs, specifically those associated with the Epstein-Barr virus (EBV), in neurological and central nervous system diseases. The study aims to understand how these tiny RNAs can serve as biomarkers for diagnosing conditions caused by EBV, particularly in immunocompromised individuals. By analyzing the expression patterns of these tiny RNAs in bodily fluids, the research seeks to establish a connection between viral infection and brain dysfunction. Patients may be involved in providing samples to help identify these biomarkers.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools for brain diseases associated with gammaherpesvirus infections.
How similar studies have gone: Previous research has shown promise in using microRNAs as biomarkers for various diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Nakanishi, Kotaro — Ohio State University
- Study coordinator: Nakanishi, Kotaro
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.