Condition

Myasthenia Gravis clinical trials and research

• 41Clinical trials
• 16NIH research projects
• 28Countries

Newest Myasthenia Gravis clinical trials

All recruiting trials (41)

• MG patient registry to track long-term experiences and treatment patterns

  This registry collects information from adults with myasthenia gravis to see how symptoms and quality of life change over time and how treatments relate to those changes.

  Recruiting Autoimmune Neurology Alliance · Framingham, Massachusetts · NCT07761026

• Ublituximab maintenance after efgartigimod response in myasthenia gravis

  This study tests whether giving ublituximab as maintenance after a positive response to efgartigimod helps adults with myasthenia gravis.

  Recruiting at 7 sites Phase 2 TG Therapeutics, Inc. · Colorado Springs, Colorado and 6 other locations · NCT07673744

• Pregnant Women with Neuroimmune Diseases: A long-term follow-up study

  This study follows women with neuroimmune diseases and healthy controls through pregnancy and up to ten years to see how pregnancy affects disease activity and outcomes for both mother and baby.

  Recruiting Third Affiliated Hospital, Sun Yat-Sen University · Guangzhou, Guangdong · NCT07653984

• Early ravulizumab for adults with myasthenic crisis in the ICU

  This project will test whether giving ravulizumab early to adults with AChR-positive generalized myasthenia gravis who are in the ICU for a myasthenic crisis helps speed recovery.

  Recruiting at 5 sites Centre Hospitalier Universitaire de Nice · Nice, Alpes-maritimes and 7 other locations · NCT07411963

• KITE-363 treatment for relapsed or refractory autoimmune neurologic diseases

  This study will test whether KITE-363 is safe and can help people with relapsed or treatment-resistant autoimmune neurologic diseases such as MS, CIDP, and myasthenia gravis.

  Recruiting at 10 sites Phase 1 Gilead Sciences · Newport Beach, California and 9 other locations · NCT07304154

• ADAPT Forward master protocol testing multiple regimens for generalized myasthenia gravis

  This platform tests several drug regimens, including efgartigimod IV and empasiprubart IV, in adults with generalized myasthenia gravis to find safer and more effective treatment combinations.

  Recruiting at 37 sites argenx · Carlsbad, California and 36 other locations · NCT07294170

• Adding empasiprubart to efgartigimod for AChR-antibody positive generalized myasthenia gravis

  This trial will test whether adding empasiprubart to efgartigimod infusions helps people with AChR-antibody positive generalized myasthenia gravis who have only had a partial response to efgartigimod.

  Recruiting at 33 sites Phase 2 argenx · Carlsbad, California and 32 other locations · NCT07284420

• IM-101 for adults with generalized and ocular myasthenia gravis

  This trial will try IM-101, a C5 inhibitor, in adults with AChR antibody–positive generalized myasthenia gravis and later include AChR antibody–negative generalized and ocular myasthenia gravis to see if it is safe and helps symptoms.

  Recruiting at 4 sites Phase 1/2 ImmunAbs Inc. · Altamonte Springs, Florida and 24 other locations · NCT07250750

• Nipocalimab versus efgartigimod for generalized myasthenia gravis

  This trial will test whether nipocalimab or efgartigimod works better to reduce muscle weakness in adults with AChR-positive generalized myasthenia gravis who have meaningful symptoms despite stable therapy.

  Recruiting at 30 sites Phase 3 Janssen Research & Development, LLC · Fullerton, California and 30 other locations · NCT07217587

• Multimodal digital assessment for myasthenia gravis.

  This project will try a multimodal digital system using facial and eye-movement videos, speech and limb motion recordings, and physiological sensors to see if it can measure symptom severity in adults with myasthenia gravis.

  Recruiting Huashan Hospital · Shanghai · NCT07146425

• Wearable monitoring of walking and arm movement in adults with neuromuscular or metabolic movement disorders

  This project uses a wrist/ankle wearable to continuously monitor walking and upper-limb movement in ambulant adults with neuromuscular diseases or obesity to see if digital measures like stride speed track real-life motor function.

  Recruiting Centre Hospitalier Universitaire de Liege · Liège · NCT07136844

• BAFF‑R CAR T‑cell treatment for refractory neuroimmune diseases

  This trial will try personalized BAFF‑R CAR T cells to reduce disease activity in people with hard‑to‑treat conditions such as CIDP, NMOSD, myasthenia gravis, and inflammatory myopathies.

  Recruiting Phase 1/2 Tianjin Medical University General Hospital · Tianjin, Tianjin Municipality · NCT07022197

• Pregnancy registry for women with chronic neurological conditions

  This study is collecting information and samples from pregnant women with chronic neurological conditions to see how pregnancy affects their health and their baby's development.

  Recruiting University of California, San Francisco · San Francisco, California · NCT06940323

• Universal CD19/BCMA CAR T-cell therapy for relapsed or refractory neurological autoimmune diseases

  This will test whether a single infusion of universal CD19/BCMA CAR T-cells given after chemotherapy helps adults with relapsed or refractory neurological autoimmune diseases who have CD19- or BCMA-positive B cells.

  Recruiting Early Phase 1 Tianjin Huanhu Hospital · Tianjin · NCT06939166

• Using AI to help manage Myasthenia Gravis

  This study is testing a voice-based AI robot to see if it can help people with Myasthenia Gravis manage their health and get support more easily.

  Recruiting National Taipei University of Nursing and Health Sciences · New Taipei City, Tamsui District · NCT06879210

• Shortness of breath in autoimmune myasthenia gravis: causes and testing

  We will see if patient-reported symptoms and specific clinical tests can identify the causes of shortness of breath in adults with autoimmune myasthenia gravis.

  Recruiting Institut de Myologie, France · Paris · NCT06866652

• Validation of a screening program for undiagnosed myasthenia gravis using social media and self-assessment

  This study is testing a self-assessment tool shared on social media to help people with possible myasthenia gravis symptoms find out if they should see a doctor for further evaluation.

  Recruiting ZS Associates · Evanston, Illinois · NCT06866483

• Zilucoplan for French patients with anti‑AChR myasthenia gravis — three‑month outcomes

  This project will try Zilucoplan (Zilbrysq) in French patients with anti‑AChR myasthenia gravis to see if muscle strength and quality of life improve over three months while tracking side effects.

  Recruiting Centre Hospitalier Universitaire de Nice · Nice, Alpes Maritimes · NCT06815133

• Comparing tongue diagnosis in myasthenia gravis patients and healthy individuals

  This study is testing if looking at tongue images can help doctors better understand myasthenia gravis by comparing the tongues of patients with the tongues of healthy people.

  Recruiting National Taipei University of Nursing and Health Sciences · New Taipei City, Tamsui District · NCT06754020

• Using smartphone recordings to assess symptoms of Myasthenia Gravis

  This study is testing if smartphone recordings can help track symptoms like speech problems and fatigue in people with Myasthenia Gravis.

  Recruiting Leiden University Medical Center · Leiden, South Holland and 1 other locations · NCT06743490

• SYS6020 CAR T-cell therapy for refractory generalized myasthenia gravis

  This trial will try SYS6020 CAR T-cell infusion in adults with refractory generalized myasthenia gravis to see if it is safe and reduces symptoms.

  Recruiting Phase 1 CSPC ZhongQi Pharmaceutical Technology Co., Ltd. · Jinan · NCT06688435

• Treatment of generalized myasthenia gravis with a new CAR-T therapy

  This study is testing a new CAR-T therapy to see if it can safely help adults with generalized myasthenia gravis feel better.

  Recruiting at 14 sites Phase 1 Gilead Sciences · Los Angeles, California and 13 other locations · NCT06626919

• Registry for people living with Myasthenia Gravis

  This study is collecting information from people with Myasthenia Gravis to understand their experiences, symptoms, and treatments over time.

  Recruiting Myasthenia Gravis Foundation of America · Westborough, Massachusetts · NCT06617741

• Identifying biomarkers for autoimmune diseases affecting the nervous system

  This study is trying to find specific markers in the blood of people with autoimmune diseases affecting the nervous system, like Multiple Sclerosis, to help with early diagnosis and better treatment options.

  Recruiting Tongji Hospital · Wuhan · NCT06502015

• Comparing light and moderate exercise for people with Myasthenia Gravis

  This study is testing whether light exercise is just as helpful as moderate exercise for people with Myasthenia Gravis over 12 weeks of group sessions.

  Recruiting HealthPartners Institute · Saint Paul, Minnesota · NCT06491238

• Evaluating NMD670 for treating Myasthenia Gravis in adults

  This study is testing if a new medication called NMD670 can help adults with Myasthenia Gravis feel better by comparing different doses to a placebo.

  Recruiting at 33 sites Phase 2 NMD Pharma A/S · Carlsbad, California and 39 other locations · NCT06414954

• Evaluating a new CAR-T therapy for severe Myasthenia Gravis

  This study is testing a new CAR-T therapy to see if it can help adults with severe myasthenia gravis who haven't found relief from standard treatments.

  Recruiting Phase 1 Tang-Du Hospital · Xi'an, Shaanxi · NCT06371040

• Safety assessment of efgartigimod exposure during pregnancy and breastfeeding

  This study is trying to see if efgartigimod is safe for pregnant women and breastfeeding mothers, and how it affects their babies.

  Recruiting at 4 sites argenx · Morgantown, West Virginia and 3 other locations · NCT06299748

• Safety study of patients treated with efgartigimod for Myasthenia Gravis

  This study is testing how safe the medication efgartigimod is for people with generalized Myasthenia Gravis who are just starting treatment or are in their first treatment cycle.

  Recruiting at 35 sites argenx · San Francisco, California and 34 other locations · NCT06298565

• Collecting saliva samples to study MuSK myasthenia gravis

  This study is collecting saliva samples from people with MuSK myasthenia gravis to see if certain genes are linked to the condition and to help find new treatments.

  Recruiting George Washington University · Washington D.C., District of Columbia · NCT06259071

• C-CAR168 treatment for autoimmune diseases not responding to standard therapy

  This study is testing a new treatment called C-CAR168 to see if it can help adults with autoimmune diseases that haven't improved with standard therapies.

  Recruiting Phase 1 RenJi Hospital · Shanghai, Shanghai Municipality · NCT06249438

• Registry for patients with Myasthenia Gravis in China

  This study is creating a national registry for people with Myasthenia Gravis in China to track their health and treatment over ten years.

  Recruiting at 16 sites Huashan Hospital · Beijing, Beijing Municipality and 15 other locations · NCT06241521

• Anti-CD19 CAR T-Cell Therapy for Refractory Myasthenia Gravis

  This study is testing a new CAR T-cell therapy to see if it can help adults with tough-to-treat myasthenia gravis feel better.

  Recruiting at 22 sites Phase 2/3 Kyverna Therapeutics · Los Angeles, California and 21 other locations · NCT06193889

• Registry for tracking myasthenia gravis patients

  This study is tracking the experiences of myasthenia gravis patients over 10 years to see how their treatment and symptoms affect their daily lives and well-being.

  Recruiting at 8 sites Vitaccess Ltd · Orange, California and 7 other locations · NCT06064461

• Digital self-assessment tool for monitoring Myasthenia Gravis

  This study is testing a new mobile app that helps people with Myasthenia Gravis track their symptoms and daily activities to see if it works as well as regular doctor visits.

  Recruiting at 15 sites Ad scientiam · Aurora, Colorado and 18 other locations · NCT05564936

• Nipocalimab treatment for children with generalized myasthenia gravis

  This study is testing a new treatment called nipocalimab to see if it can help children with generalized myasthenia gravis who haven't responded well to other therapies.

  Recruiting at 15 sites Phase 2/3 Janssen Research & Development, LLC · Phoenix, Arizona and 18 other locations · NCT05265273

• Evaluating Nipocalimab for Adults with Generalized Myasthenia Gravis

  This study is testing a new drug called nipocalimab to see if it can help adults with generalized myasthenia gravis feel stronger and improve their daily activities compared to a placebo.

  Recruiting at 68 sites Phase 3 Janssen Research & Development, LLC · Paradise Valley, Arizona and 111 other locations · NCT04951622

• Using CT103A cells to treat autoimmune diseases of the nervous system

  This study is testing if a new treatment using CT103A cells can help people with certain autoimmune diseases affecting the nervous system feel better.

  Recruiting Early Phase 1 Tongji Hospital · Wuhan, Hubei · NCT04561557

• Improving diagnosis and understanding of myasthenia gravis in Chinese patients

  This study is trying to improve how doctors diagnose and understand myasthenia gravis in Chinese patients by tracking the health of 300 people with the condition over time.

  Recruiting at 4 sites Huashan Hospital · Shanghai, Shanghai Municipality and 3 other locations · NCT04535843

• Registry for Myasthenia Gravis patients at Yale University

  This study is collecting information from people with Myasthenia Gravis at Yale University to help understand the disease better and improve care for patients.

  Recruiting Yale University · New Haven, Connecticut · NCT03792659

• Registry for patients with rare diseases

  This study is creating a central registry for people with rare diseases to help connect them with researchers and improve treatments.

  Recruiting Sanford Health · Sioux Falls, South Dakota · NCT01793168

NIH-funded research (16)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how autoimmunity causes myasthenia gravis

  This project looks at why the immune system attacks the nerve-muscle connection in myasthenia gravis and how different patient groups are affected.

  NIH research Yale University · New Haven, United States · NIH-11617060

• Biological age in myasthenia gravis: guiding who responds to treatment

  A patient-friendly look at how a person’s biological age, not just their calendar age, might predict how MG patients respond to treatment and how treatments could even reduce biological aging.

  NIH research George Washington University · Washington, United States · NIH-11414989

• CapTURE-MG: A patient-friendly MG data toolkit in a common EHR

  A multi-site effort to use a streamlined MG toolkit inside the Epic EHR to collect consistent, real-world information about myasthenia gravis from routine care.

  NIH research George Washington University · Washington, United States · NIH-11414984

• Rare Disease Network for Myasthenia Gravis

  A nationwide effort to improve diagnosis, monitoring, and trial readiness for people with myasthenia gravis through biomarker work and better care tools.

  NIH research George Washington University · Washington, United States · NIH-11414937

• Understanding how autoimmune attacks cause myasthenia gravis

  Researchers are studying how the immune system mistakenly targets the neuromuscular junction in myasthenia gravis to identify why the disease starts and how it progresses.

  NIH research Yale University · New Haven, United States · NIH-11372042

• Mechanistically informed deep learning to study autoreactive B cells in Myasthenia Gravis

  A study using advanced computer models to find hidden immune-cell signals in people with Myasthenia Gravis, including those who don’t yet show detectable antibodies.

  NIH research Yale University · New Haven, United States · NIH-11366548

• Heterogeneity in autoimmune myasthenia gravis: classifying disease variants to guide personalized therapies

  This research looks at different forms of myasthenia gravis to understand how unique immune factors drive the disease so doctors can tailor treatments.

  NIH research Yale University · New Haven, United States · NIH-11349770

• Antigen-targeted biologic therapy for myasthenia gravis

  A new biologic therapy is being developed to neutralize the harmful antibodies that attack the muscles in myasthenia gravis, offering a targeted alternative to broad immunosuppression.

  NIH research Sierra Biopharma, INC. · Davis, United States · NIH-11254976

• Wearable device and phone app to monitor myasthenia gravis symptoms

  A wearable sensor and mobile app will continuously track muscle weakness, speech changes, and drooping eyelids for people with myasthenia gravis.

  NIH research Biosensics, LLC · Newton, UNITED STATES · NIH-11237038

• Biological aging and treatment response in myasthenia gravis

  This project measures biological age from blood and tissue samples in people with myasthenia gravis to see if it helps explain who responds to treatments like thymectomy.

  NIH research George Washington University · Washington, United States · NIH-11171996

• Embedding clinical tools into electronic records for myasthenia gravis care

  This project adds a simple toolkit into doctors' electronic health records to collect consistent clinical information about people with myasthenia gravis during routine care.

  NIH research George Washington University · Washington, United States · NIH-11171995

• Myasthenia Gravis Patient Network

  This network connects people with myasthenia gravis to researchers to improve diagnosis, find markers in blood and clinical data, and make it easier for patients to join better clinical trials.

  NIH research George Washington University · Washington, United States · NIH-11171992

• How immune antibodies damage the neuromuscular connection in myasthenia gravis

  This project looks at how antibodies made by the immune system weaken muscles in people with myasthenia gravis.

  NIH research Yale University · New Haven, United States · NIH-11127030

• Targeting autoimmune responses in Myasthenia Gravis using engineered T cells

  This study is testing a new treatment for Myasthenia Gravis by creating special immune cells that can help calm down the body's attack on muscles, and it's designed to help people who struggle with this condition.

  NIH research George Washington University · Washington, United States · NIH-11121075

• Understanding Myasthenia Gravis

  This work aims to better understand why the immune system attacks the body in Myasthenia Gravis, a condition causing muscle weakness.

  NIH research Yale University · New Haven, United States · NIH-10904878

• Using wearable sensors to monitor symptoms in myasthenia gravis patients

  This study is creating a handy wearable device and a mobile app to help people with myasthenia gravis keep track of their symptoms every day, making it easier for them and their doctors to understand how they're doing without needing to go to the clinic all the time.

  NIH research Biosensics, LLC · Newton, UNITED STATES · NIH-10710321

Related topics

Quick answers

How many Myasthenia Gravis clinical trials are recruiting right now?

41, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 28 countries. The most sites are in United States (23 trials), China (12 trials), Spain (8 trials), Germany (7 trials), Italy (7 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 5, Phase 2: 3, Phase 2/3: 2, Early Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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