Improving diagnosis and understanding of myasthenia gravis in Chinese patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to enhance the clinical capacity for diagnosing and understanding the natural history of myasthenia gravis (MG) among Chinese patients. It plans to recruit 300 patients with MG, documenting their conditions and following them over time. The study will focus on the management of screening tests and the manifestations of the cohort, utilizing biomarkers and omics data for analysis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* fluctuating muscle weakness and fatigability, along with one of the below:
* more than 10% amplitude decrement in low frequency repetitive nerve stimulation,less than 10% amplitude increment in high frequency repetitive nerve stimulation;
* anti-AChR or MuSK antibody positivity;
* positive to the neostigmine test;
* understanding and assigning the informed consent form, and having a good compliance with the follow up.

Exclusion Criteria:

* excluding the possible diagnosis of Lambert-Eaton syndrome, congenital myasthenia syndrome,botulism injection, chronic progressive extraocular ophthalmoplegia, etc;
* poor compliance to the follow up.

Where it's running

• Shanghai Chest Hospital
  Shanghai, Shanghai Municipality, China Recruiting
• Obsterics and Gynecology Hospital of Fudan University
  Shanghai, Shanghai Municipality, China Recruiting
• Children's Hospital of Fudan University
  Shanghai, Shanghai Municipality, China Recruiting
• Huashan Hospital
  Shanghai, China Recruiting

Study contacts

• Study coordinator: Chongbo Zhao, MD
• Email: zhao_chongbo@fudan.edu.cn
• Phone: 86-021-52889999

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Early ravulizumab for adults with myasthenic crisis in the ICU

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• KITE-363 treatment for relapsed or refractory autoimmune neurologic diseases

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• ADAPT Forward master protocol testing multiple regimens for generalized myasthenia gravis

  This platform tests several drug regimens, including efgartigimod IV and empasiprubart IV, in adults with generalized myasthenia gravis to find safer and more effective treatment combinations.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.