Wearable monitoring of walking and arm movement in adults with neuromuscular or metabolic movement disorders

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, longitudinal observational project will enroll about 300 ambulant adults at specialist centers in Liège, Belgium and follow them for up to two years (six months for disorders of the neuromuscular junction). Participants will wear the Syde® magneto-inertial sensor on the wrist and/or ankle for continuous home monitoring, alongside standardized in-clinic tests such as the 6-minute walk test, 10-meter test, stair-climbing and muscle dynamometry. The primary focus is on digital mobility outcomes, notably the 95th centile of stride velocity (SV95C), to determine their reliability and practical use as objective endpoints across several diseases. Data collection includes regular clinic visits and remote wearable data to capture daily-life motor performance and change over time.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Ambulant patients (i.e. able to walk 10 meters without assistance)
* Confirmed diagnosis by the investigator based on current gold standard in his/her disease (genetic testing, clinical criteria, etc.)

  * Myotonic dystrophy type 1 (DM1) and Charcot-Marie-Tooth (CMT) patients should present sensitive of motor signs on physical examination.
  * Myasthenic patients should be seropositive, and Myasthenia Gravis Foundation of America (MGFA) class II to IV.
  * Patient with morbid obesity (Body Mass Index\> or = 35 at inclusion visit).
* Signed informed consent form by patient him/herself and patient willing and able to comply with all study procedures.

Exclusion Criteria:

* Non-ambulant patients
* Patients with extreme cognitive disorders that limit their understanding of the exercises to be performed
* Patients who have undergone a surgical procedure or who have experienced recent trauma (within fewer than 6 months) affecting the upper or lower limbs
* A concomitant chronic or acute neurological, endocrine, infectious, allergic, or inflammatory pathology within the 3-week period immediately prior to inclusion
* Patients who are participating in an interventional clinical trial
* Pregnant or breastfeeding women

Where it's running

• Centre de référence des maladies neuromusculaire, Centre Hospitalier Régional de la Citadelle
  Liège, Belgium Recruiting

Study contacts

• Principal investigator: Laurent Servais, MD — Centre Hospitalier Universitaire de Liege
• Study coordinator: Nicolas Bovy
• Email: Nicolas.Bovy@citadelle.be
• Phone: +3243218095

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Research network for hereditary spastic paraplegia and primary lateral sclerosis

  This study is trying to learn more about hereditary spastic paraplegia and primary lateral sclerosis by enrolling people with specific types of the condition to help find better treatments and understand how these diseases progress.

  Recruiting Boston Children's Hospital · Miami, Florida and 10 other locations · NCT06553976

• Weight-loss drugs tirzepatide vs. semaglutide in adults with obesity

  This trial tests whether 12 weeks of tirzepatide or semaglutide have different effects on energy balance in adults with obesity but no diabetes.

  Recruiting Phase 4 McMaster University · Hamilton, Ontario · NCT07900074

• Rare Disease Registry for Movement Disorders in Southern Anhui

  This project is creating a registry to collect information from adults with motor neuron diseases, spinocerebellar ataxias, hereditary muscular dystrophy, or hereditary spastic paraplegia in Southern Anhui.

  Recruiting First Affiliated Hospital of Wannan Medical College · Wuhu, Anhui · NCT07838883

• Body composition changes after starting GLP-1 therapies in adults with obesity or type 2 diabetes

  This study will follow adults with obesity and/or type 2 diabetes who are starting or adjusting a GLP-1 receptor agonist to see how their muscle and fat change over about a year.

  Recruiting at 2 sites Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran · Mexico City, Mexico City and 1 other locations · NCT07835360

• Synbiotic for cognitive function in adults with obesity

  A synbiotic containing Lactobacillus acidophilus and inulin is being tested to see if it improves cognitive function in adults with obesity and mild cognitive impairment.

  Recruiting Anahuac University · Huixquilucan, State of Mexico · NCT07810517

• Natural history of atypical parkinsonian syndromes: a multi-center observation

  This study follows people with APS like MSA, DLB, PSP, and CBD to see how their symptoms and brain images change over time.

  Recruiting at 6 sites Second Affiliated Hospital of Soochow University · Changshu, Jiangsu and 19 other locations · NCT07805967

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.