Pregnant Women with Neuroimmune Diseases: A long-term follow-up study

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study tracks 50 women of childbearing age with NMOSD, MS, autoimmune encephalitis, myasthenia gravis, GBS, or MOGAD, plus 50 healthy controls, to observe relapse rates, symptoms, imaging, treatments, and blood profiles during pregnancy and postpartum. Data include EDSS scores and MRI results, maternal drug levels, and neonatal development, with a plan for extended follow-up up to ten years. The primary aim is to generate detailed clinical data to help clinicians optimize disease management during pregnancy and after delivery. Enrollment prioritizes voluntary consent and complete personal information, with geographic restriction to a single Chinese center. The study is observational and does not specify a treatment intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient Group: A total of fifty participants are expected to be enrolled.

  1. Women aged 20-55 years with childbearing potential.
  2. Voluntary informed consent.
  3. Availability of complete personal information.
  4. A confirmed diagnosis of neuromyelitis optica spectrum disorder (NMOSD), multiple sclerosis (MS), autoimmune encephalitis, myasthenia gravis, Guillain-Barré syndrome, or myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD).

Healthy Control Group: A total of fifty healthy women are expected to be included.

1. Age- and sex-matched women of childbearing age with plans for pregnancy
2. Voluntary informed consent.
3. Availability of complete personal information.

Exclusion Criteria:

* Patient Group:

  1. Patients with an undetermined or unconfirmed diagnosis.
  2. Incomplete personal information that cannot be obtained through follow-up.
  3. Participants who voluntarily withdrew from the study and revoked informed consent.

Healthy Control Group:

1. Individuals diagnosed with neuroimmune-related disorders.
2. Incomplete personal information that cannot be obtained through follow-up.
3. Participants who voluntarily withdrew from the study and revoked informed consent.

Where it's running

• The Third Affiliated Hospital, Sun Yat-sen University
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Study coordinator: Wei Qiu, Ph.D
• Email: qiuwei120@vip.163.com
• Phone: 15899968330

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using CT103A cells to treat autoimmune diseases of the nervous system

  This study is testing if a new treatment using CT103A cells can help people with certain autoimmune diseases affecting the nervous system feel better.

  Recruiting Early Phase 1 Tongji Hospital · Wuhan, Hubei · NCT04561557

• Universal CD19/BCMA CAR T-cell therapy for relapsed or refractory neurological autoimmune diseases

  This will test whether a single infusion of universal CD19/BCMA CAR T-cells given after chemotherapy helps adults with relapsed or refractory neurological autoimmune diseases who have CD19- or BCMA-positive B cells.

  Recruiting Early Phase 1 Tianjin Huanhu Hospital · Tianjin · NCT06939166

• Identifying biomarkers for autoimmune diseases affecting the nervous system

  This study is trying to find specific markers in the blood of people with autoimmune diseases affecting the nervous system, like Multiple Sclerosis, to help with early diagnosis and better treatment options.

  Recruiting Tongji Hospital · Wuhan · NCT06502015

• KITE-363 treatment for relapsed or refractory autoimmune neurologic diseases

  This study will test whether KITE-363 is safe and can help people with relapsed or treatment-resistant autoimmune neurologic diseases such as MS, CIDP, and myasthenia gravis.

  Recruiting at 10 sites Phase 1 Gilead Sciences · Newport Beach, California and 9 other locations · NCT07304154

• Using ultra-high field and metabolic MRI to understand resilience and degeneration in the aging and diseased brain

  This project will try advanced 3T and 7T MRI scans, including sodium and phosphorus imaging, to see if metabolic and connectivity changes explain resilience and degeneration in adults with MS, NMOSD, MOGAD, Alzheimer’s, Parkinson’s, or healthy aging.

  Recruiting Assistance Publique Hopitaux De Marseille · Marseille · NCT07202494

• Pregnancy registry for women with chronic neurological conditions

  This study is collecting information and samples from pregnant women with chronic neurological conditions to see how pregnancy affects their health and their baby's development.

  Recruiting University of California, San Francisco · San Francisco, California · NCT06940323

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.