Condition

Muscle Weakness clinical trials and research

• 18Clinical trials
• 5NIH research projects
• 1New in 30 days
• 10Countries

Newest Muscle Weakness clinical trials

All recruiting trials (18)

• Targeted NMES to improve breathing and leg/extra muscle strength in COPD

  This study tests whether targeted neuromuscular electrical stimulation helps people with COPD see improvements in breathing muscle function and overall muscle strength.

  Recruiting Universitas Padjadjaran · Bandung, West Java · NCT07910006

• Low-Volume PENG Block With Dexamethasone After Hip Replacement

  This trial tests whether a smaller PENG block with dexamethasone provides similar pain relief but preserves quadriceps strength after hip replacement, compared with the standard-volume PENG block.

  Recruiting Phase 4 Ain Shams University · Cairo, Cairo Governorate · NCT07855341

• Muscle Health Endotypes in Childhood Cancer Survivors

  This study tests whether adult survivors of childhood cancer have different muscle health endotypes using advanced imaging and neuromuscular testing to guide future targeted interventions.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07531498

• Preoperative factors that influence recovery of leg strength after lumbar microdiscectomy

  This project will try to find which before-surgery factors predict how well adults with leg weakness from a herniated lower-back disc get their strength back after microdiscectomy.

  Recruiting at 3 sites Aristotle University Of Thessaloniki · Kavala and 2 other locations · NCT07413302

• See if cross-education helps prevent weakness during short-term wrist immobilization in midlife women

  Researchers are testing whether training the opposite arm can help keep strength and muscle size in the immobilized wrist for midlife women.

  Recruiting Kansas State University · Manhattan, Kansas · NCT07166198

• Early check of quadriceps strength in ICU patients on invasive ventilation

  This study tests whether early measurement of quadriceps strength using dynamometry and 3D ultrasound can help track recovery in adults in the ICU who are on invasive mechanical ventilation.

  Recruiting Nantes University Hospital · Nantes, Loire Atlantique · NCT07069959

• Making lower-limb exoskeletons usable for children and young adults

  This project will test whether a wearable leg exoskeleton, sometimes paired with electrical muscle stimulation, can help children and young adults with cerebral palsy, muscular dystrophy, spina bifida, or incomplete spinal cord injury walk and move during everyday tasks.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06998134

• Examining muscle function in survivors of childhood leukemia

  This study is trying to see how cancer treatment affects muscle strength and function in survivors of childhood leukemia compared to healthy kids.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT06819475

• Nerve stimulation for children with sciatic nerve injuries

  This study is testing if a new nerve stimulation treatment can help children with sciatic nerve injuries recover better than just standard therapy alone.

  Recruiting Azeem Hospital, Multan · Multan, Punjab Province · NCT06781060

• Treatment of generalized myasthenia gravis with a new CAR-T therapy

  This study is testing a new CAR-T therapy to see if it can safely help adults with generalized myasthenia gravis feel better.

  Recruiting at 14 sites Phase 1 Gilead Sciences · Los Angeles, California and 13 other locations · NCT06626919

• Evaluating creatine supplementation for breast cancer survivors

  This study is testing if taking creatine can help breast cancer survivors improve their strength, endurance, and body composition after finishing chemotherapy.

  Recruiting The University of Texas Medical Branch, Galveston · Galveston, Texas · NCT06395506

• Elastic-band exercises to build strength and lower depression in hospitalized older adults

  This program will test whether a five-day, low-resistance elastic band exercise routine can increase muscle mass and strength and reduce fear of falling and depression in hospitalized people aged 65 and older.

  Recruiting National Taiwan University · Taipei, Taiwan · NCT06205147

• Impact of weight loss on fat tissue signaling in muscles

  This study is testing how losing weight affects fat tissue in muscles and whether it helps people with obesity improve their insulin sensitivity.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT06129110

• Effects of Depo-Medrol on Psoas Muscle After Lumbar Spine Surgery

  This study tests if giving a corticosteroid called Depo-Medrol to the psoas muscle after lumbar spine surgery can help reduce thigh pain and improve hip strength compared to patients who don’t receive the injection.

  Recruiting Phase 4 UConn Health · Farmington, Connecticut · NCT05929755

• Understanding muscle recovery in ICU survivors

  This study looks at how well muscle function and physical abilities recover in people who have survived serious illnesses and spent time in the ICU.

  Recruiting University of Kentucky · Birmingham, Alabama and 2 other locations · NCT05537298

• Comparing surgical approaches for hip surgery and their impact on limping

  This study is testing whether using a lateral or posterior surgical approach for hip replacement surgery affects the chances of patients having a limp one year later.

  Recruiting Sahlgrenska University Hospital · Mölndal · NCT05216666

• Surgical treatment for limping after hip replacement using Achilles tendon

  This study tests if using a piece of Achilles tendon to fix the gluteus medius can help people who still limp after hip replacement feel better compared to just doing physical therapy.

  Recruiting Sahlgrenska University Hospital · Mölndal · NCT05206838

• Study on muscle weakness after surgery in intensive care patients

  This study is testing if changes in blood and muscle samples from surgical patients can help us understand and find markers for muscle weakness that happens after being in intensive care.

  Recruiting Technical University of Munich · Vienna, State of Vienna and 2 other locations · NCT03810768

NIH-funded research (5)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how aging affects muscle strength

  This study is looking at how changes in nerve cells might make muscles weaker as we get older, and it hopes to find new ways to help older adults stay strong and independent.

  NIH research Ohio University Athens · Athens, United States · NIH-11056056

• Investigating how unacylated ghrelin affects muscle weakness in aging and cancer.

  This study is looking at whether a hormone called unacylated ghrelin can help older adults and cancer patients keep their muscles strong and prevent muscle loss, with the hope of finding a new way to support those dealing with muscle weakness.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11017108

• Antioxidant treatment for heart failure and muscle weakness in older women

  This study is looking at how a special antioxidant treatment might help postmenopausal women with heart failure that makes it hard for them to exercise and causes muscle weakness, with the goal of finding better ways to improve their strength and stamina.

  NIH research Duke University · Durham, United States · NIH-10991553

• Investigating mutations in a protein linked to muscle weakness and tremors

  This study is looking at how changes in a specific protein called Myosin Binding Protein-C can lead to muscle problems like weakness and tremors, and it aims to help patients by figuring out how these changes affect muscle function and finding new ways to treat these issues.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-10908598

• Investigating how unacylated ghrelin affects muscle weakness and loss in aging and cancer patients

  This study is looking at how a hormone called unacylated ghrelin might help older adults and cancer patients keep their muscles strong and healthy, which could improve their overall quality of life.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-10791902

Related topics

Quick answers

How many Muscle Weakness clinical trials are recruiting right now?

18, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United States (9 trials), Sweden (2 trials), Indonesia (1 trial), Austria (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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