Early check of quadriceps strength in ICU patients on invasive ventilation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on adults in the ICU who have been on invasive mechanical ventilation for at least four days. It aims to assess quadriceps muscle strength early using manual dynamometry and 3D ultrasound, alongside traditional MRC scoring, to better predict medium-term functional recovery. The approach addresses limitations of the MRC scale by incorporating objective strength measures to monitor muscle recovery during critical illness. Participants must be conscious, cooperative, and have a leg extension strength of at least 3/5 on one side, with informed consent obtained. Conducted at Nantes University Hospital, the study does not specify a control group or interventional treatment, but seeks to characterize muscle recovery trajectories in ICU-acquired weakness.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged \> 18 years
* Hospitalized in an ICU
* Treated with invasive mechanical ventilation (MV) for at least 4 days during their stay (may be extubated at the time of inclusion)
* Conscious and cooperative patients: ability to respond appropriately to the following commands: open and close eyes, look at me, nod your head, stick out your tongue, raise your eyebrows when I count to five
* MRC score ≥ 3/5 for the "Leg Extension" function on either the left or right side
* Informed consent obtained (no opposition)

Exclusion Criteria:

* Pregnant or breastfeeding women
* Fracture or amputation of a lower limb
* Acute or chronic brain or spinal cord injury responsible for hemiplegia or paraplegia
* Unstable spinal injury
* Neurodegenerative or chronic neurological disease
* Guillain-Barré Syndrome
* Myasthenia Gravis
* Acute deep vein thrombosis of the lower limbs treated within the last 48 hours
* Pre-existing motor deficit in a lower limb before the ICU stay, of any cause
* Incarcerated or legally protected individuals (guardianship, curatorship)
* Individuals without social protection

Where it's running

• Nantes University Hospital
  Nantes, Loire Atlantique, France Recruiting

Study contacts

• Study coordinator: Research and Innovation Departement of Nantes UH
• Email: bp-prom-regl@chu-nantes.fr
• Phone: +33253482810

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.