Condition

Muscle Atrophy clinical trials and research

• 11Clinical trials
• 20NIH research projects
• 5Countries

Newest Muscle Atrophy clinical trials

All recruiting trials (11)

• Protein boost during the luteal phase to help protect muscle

  This study tests whether increasing daily protein intake by 12% during the luteal phase can help prevent muscle breakdown in premenopausal women aged 18–35.

  Recruiting Sam Houston State University · Conroe, Texas and 1 other locations · NCT07843095

• Postoperative NMES on both thighs with protein during abdominal cancer surgery

  This study tests whether neuromuscular electrical stimulation of both thighs after major abdominal cancer surgery helps preserve leg muscle, and whether adding protein drinks improves the effect.

  Recruiting University of Nottingham · Derby, Derbyshire · NCT06964438

• Assessing muscle thickness changes in heart failure patients

  This study is testing how muscle thickness changes in heart failure patients receiving advanced treatments like heart transplants or assist devices to see how it affects their recovery.

  Recruiting Tufts Medical Center · Boston, Massachusetts · NCT06253104

• Essential amino acid supplementation for patients with femoral fractures

  This study is testing if taking essential amino acids for four weeks after surgery can help people with femoral fractures recover better and keep their muscle strength.

  Recruiting Phase 2 University of Iowa · Iowa City, Iowa and 1 other locations · NCT06050668

• Combining muscle activation and high-protein nutrition to improve muscle health in ICU patients

  This study is testing if giving high-protein nutrition along with muscle activation exercises can help critically ill patients in the ICU keep their muscles strong and recover better.

  Recruiting at 2 sites Technical University of Munich · Vienna, State of Vienna and 3 other locations · NCT05919940

• Dietary protein intervention for muscle recovery in heart failure patients

  This study is testing if adding more protein to the diet can help heart failure patients keep their muscle mass and recover better.

  Recruiting at 2 sites Tufts Medical Center · Boston, Massachusetts and 1 other locations · NCT05627440

• Effects of mTOR Inhibition on Muscle Health in Older Adults

  This study is testing if a medication called Rapamune can help older adults with muscle loss get stronger when they do resistance exercises.

  Recruiting University of Nottingham · Derby · NCT05414292

• Comparing surgical approaches for hip surgery and their impact on limping

  This study is testing whether using a lateral or posterior surgical approach for hip replacement surgery affects the chances of patients having a limp one year later.

  Recruiting Sahlgrenska University Hospital · Mölndal · NCT05216666

• Surgical treatment for limping after hip replacement using Achilles tendon

  This study tests if using a piece of Achilles tendon to fix the gluteus medius can help people who still limp after hip replacement feel better compared to just doing physical therapy.

  Recruiting Sahlgrenska University Hospital · Mölndal · NCT05206838

• Impact of Type 2 Diabetes on Muscle Loss and Recovery in Older Adults

  This study is testing how type 2 diabetes affects muscle loss and recovery in older adults during bed rest to see if it helps us understand why they lose muscle faster.

  Recruiting AdventHealth Translational Research Institute · Orlando, Florida · NCT03761446

• Using electrical stimulation and high protein diet to aid recovery after brain hemorrhage

  This study is testing if using electrical stimulation and a high protein diet can help adults recover better after a brain hemorrhage compared to standard care.

  Recruiting University of Maryland, Baltimore · Baltimore, Maryland · NCT03201094

NIH-funded research (20)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Therapeutic approach to reduce cellular aging and improve thigh muscle recovery after ACL injury

  A research project tests a drug (metformin) to help the thigh muscle heal better after ACL injury and reconstruction.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11450887

• MG53 protein to protect aging muscles during disuse

  A small research project will explore whether increasing MG53 protein can help prevent muscle loss during periods of inactivity in aging, with the goal of protecting muscle health.

  NIH research University of Nebraska Lincoln · Lincoln, United States · NIH-11406337

• Oxidized lipids driving aging-related muscle loss

  This project explores how certain lipid molecules that are damaged or modified over time contribute to muscle weakness and loss in older adults, with the goal of identifying new ways to prevent sarcopenia.

  NIH research Oklahoma Medical Research Foundation · Oklahoma City, United States · NIH-11396249

• Role of Depp1 in muscle loss and weakness

  A study at a major hospital is exploring whether a protein called Depp1 drives muscle loss when muscles don’t get enough nutrients or oxygen, with the aim of finding ways to prevent this wasting.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11268416

• Gut bacteria therapy for muscle wasting

  This project tests whether changing gut bacteria can help prevent or reverse muscle wasting in people with cancer-related cachexia or disuse atrophy.

  NIH research University of Kentucky · Lexington, United States · NIH-11264924

• Reducing lipid oxidative damage to prevent age-related muscle loss

  This project explores whether clearing harmful lipid oxidation products and stopping their formation could protect muscles from age-related wasting.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11242061

• BNIP3 and muscle wasting in pancreatic cancer

  This work looks at whether a protein called BNIP3 drives muscle wasting in people with pancreatic cancer and whether muscle-derived blood markers could help detect cancer earlier.

  NIH research University of Chicago · Chicago, United States · NIH-11241130

• How elevated FGF-21 affects muscle loss due to mitochondrial problems

  This study is looking at how a protein called FGF-21 might play a role in muscle loss, especially for people dealing with issues like spinal cord injuries or being inactive for a long time, and it hopes to find new ways to help keep muscles healthy.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11175267

• Oxidized lipids causing muscle loss and weakness in aging

  Researchers are looking at whether oxidized fat molecules that build up in aging muscles cause muscle wasting and weakness in older adults.

  NIH research Oklahoma Medical Research Foundation · Oklahoma City, United States · NIH-11112359

• Investigating how BNIP3 and mitophagy contribute to muscle wasting in cancer patients.

  This study is looking at how a protein called BNIP3 affects muscle loss in people with pancreatic cancer, using mouse models to see how it works and checking muscle samples from patients to find out if BNIP3 can help predict muscle wasting and survival, which could lead to better ways to spot the disease early.

  NIH research University of Chicago · Chicago, United States · NIH-11073437

• Using gut bacteria to help treat muscle loss

  This study is looking at how the bacteria in our gut can affect muscle health, especially for people who have lost muscle strength due to not being active, getting older, or being sick, and it hopes to find new ways to help muscles recover and grow better, even if someone can't exercise much.

  NIH research University of Kentucky · Lexington, United States · NIH-11073142

• Understanding how gut bacteria affect muscle loss after sepsis

  This study is looking at how the bacteria in your gut might affect muscle loss after a serious infection called sepsis, and it's for people who are recovering from this condition to help find ways to keep their muscles healthy.

  NIH research University of Iowa · Iowa City, United States · NIH-11062387

• Investigating how MuRF1 affects muscle loss

  This study is looking at a protein called MuRF1 that is connected to muscle loss, and by figuring out how it works with other proteins in muscle, the researchers hope to find new ways to create treatments that can help people keep their muscles strong and healthy.

  NIH research Oklahoma Medical Research Foundation · Oklahoma City, United States · NIH-11061929

• Investigating how age-related muscle loss is influenced by specific molecules

  This study is looking at how getting older can cause muscle loss, which can make it harder to move and lead to other health problems, and it will test new treatments that might help protect muscle in older adults by targeting harmful molecules in the body.

  NIH research University of Utah · Salt Lake City, United States · NIH-10987032

• Understanding how a protein affects muscle loss

  This study is looking at a protein called Maf to see how it affects muscle loss, especially in people dealing with cancer or aging, and it hopes to find ways to help keep muscles healthy and prevent wasting.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-10948561

• Understanding how mitochondrial issues lead to muscle loss as we age.

  This study looks at how problems with tiny energy factories in our muscles, called mitochondria, can lead to muscle loss and weakness as we get older, using special mice to help understand these changes better.

  NIH research Upstate Medical University · Syracuse, United States · NIH-10931389

• Improving muscle recovery in Veterans after hospitalization

  This study is all about helping Veterans with chronic kidney disease regain their muscle strength and mass after being in the hospital, using personalized exercise plans and support to keep their muscles healthy.

  NIH research VA Eastern Colorado Health Care System · Aurora, UNITED STATES · NIH-10922332

• Understanding and improving muscle recovery in older Veterans after hospital stays

  This study is looking at ways to help older Veterans who have trouble rebuilding their muscle strength after being in the hospital, by figuring out what causes muscle loss and finding early ways to keep their muscles healthy.

  NIH research VA Salt Lake City Healthcare System · Salt Lake City, United States · NIH-10917686

• Investigating how UBR5 affects muscle loss and recovery

  This study is looking at a protein called UBR5 to see how it affects muscle loss and recovery, which could help people who are dealing with muscle weakness from long-term illnesses or not using their muscles enough.

  NIH research Oklahoma Medical Research Foundation · Oklahoma City, United States · NIH-10868891

• A new oral treatment to prevent and reverse muscle loss in older adults

  This study is testing a new oral medication designed to help older adults keep their muscles strong and healthy, especially if they’ve been less active due to things like being in bed or not moving much.

  NIH research Ridgeline Therapeutics, LLC · Houston, UNITED STATES · NIH-10761425

Related topics

Quick answers

How many Muscle Atrophy clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (6 trials), Sweden (2 trials), United Kingdom (2 trials), Austria (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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