Understanding muscle recovery in ICU survivors
Cellular and Physical Function Outcomes Leading to Failed Muscle Recovery After Critical Illness
This study looks at how well muscle function and physical abilities recover in people who have survived serious illnesses and spent time in the ICU.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 209 (estimated) |
| Ages | 18 Years and up |
| Sex | Male |
| Sponsor | University of Kentucky Academic / other |
| Locations | 3 sites (Birmingham, Alabama and 2 other locations) |
| Trial ID | NCT05537298 on ClinicalTrials.gov |
What this trial studies
This study aims to track the recovery of muscle function and physical capabilities in patients who have survived critical illnesses, particularly those who experienced ICU-acquired weakness. It will involve longitudinal assessments to evaluate physical recovery and identify cellular markers that may influence muscle recovery and contribute to long-term disability. By examining the relationship between muscle pathophysiology and physical function outcomes, the study seeks to fill knowledge gaps regarding recovery after critical illness.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 who were admitted to the ICU for sepsis or acute respiratory failure and stayed for at least 72 hours.
Not a fit: Patients with acute or chronic neurological or orthopedic conditions that prevent strength testing, or those who were not ambulatory prior to ICU admission, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved rehabilitation strategies for ICU survivors, enhancing their recovery and quality of life.
How similar studies have performed: While there is ongoing research in this area, this specific approach to understanding muscle recovery in ICU survivors is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * adult (\>18 y/o) * admission for sepsis or acute respiratory failure with at least 72 hour stay in ICU Exclusion Criteria: * acute or chronic neurologic condition * acute or chronic orthopedic condition preventing strength/functional testing * patients who were not ambulatory prior to ICU admission * patients not expected to survive \~6months after admission
Where this trial is running
Birmingham, Alabama and 2 other locations
- University of Alabama at Birmingham — Birmingham, Alabama, United States (Active_not_recruiting)
- University of Kentucky — Lexington, Kentucky, United States (Recruiting)
- Oklahoma Medical Research Foundation — Oklahoma City, Oklahoma, United States (Active_not_recruiting)
Study contacts
- Study coordinator: Kirby P Mayer, PhD
- Email: kpmaye2@uky.edu
- Phone: 859-218-0596
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.