Investigating how mild traumatic brain injury affects blood vessels in the brain related to Alzheimer's disease.
Effects of mild traumatic brain injury in a mouse model of cerebral amyloid angiopathy
['FUNDING_R03'] · NOVA SOUTHEASTERN UNIVERSITY · NIH-10844392
This study is looking at how mild brain injuries might affect blood vessel health in the brain and increase the risk of dementia, using mice to help us understand what happens after such injuries, so we can find new ways to protect brain health.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NOVA SOUTHEASTERN UNIVERSITY (nih funded) |
| Locations | 1 site (Fort Lauderdale-Davie, UNITED STATES) |
| Trial ID | NIH-10844392 on ClinicalTrials.gov |
What this research studies
This research explores the impact of mild traumatic brain injury (TBI) on cerebral amyloid angiopathy (CAA), a condition linked to Alzheimer's disease. Using a mouse model, the study aims to understand how mild TBIs may contribute to the accumulation of amyloid proteins in the brain's blood vessels, which could increase the risk of dementia. The approach involves examining the neurological changes following mild TBI and their potential long-term effects on brain health. By identifying these mechanisms, the research seeks to uncover new targets for intervention that could help prevent or mitigate dementia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced mild traumatic brain injuries, particularly those involved in contact sports or military service.
Not a fit: Patients who have not experienced any form of traumatic brain injury may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating dementia in individuals with a history of mild traumatic brain injuries.
How similar studies have performed: Previous research has shown that understanding the relationship between traumatic brain injuries and dementia can lead to significant advancements in treatment approaches, suggesting this study builds on established findings.
Where this research is happening
Fort Lauderdale-Davie, UNITED STATES
- NOVA SOUTHEASTERN UNIVERSITY — Fort Lauderdale-Davie, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROBISON, LISA SUZANNE — NOVA SOUTHEASTERN UNIVERSITY
- Study coordinator: ROBISON, LISA SUZANNE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.