Investigating how mild traumatic brain injury affects blood vessels in the brain related to Alzheimer's disease.
Official title: Effects of mild traumatic brain injury in a mouse model of cerebral amyloid angiopathy
Funded at Nova Southeastern University · NIH-10844392 · Data updated 2026-11-12
This study is looking at how mild brain injuries might affect blood vessel health in the brain and increase the risk of dementia, using mice to help us understand what happens after such injuries, so we can find new ways to protect brain health.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nova Southeastern University NIH-funded |
| Lab location | 1 site (Fort Lauderdale-Davie, UNITED STATES) |
| Project start | June 1, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $154,000 |
| NIH project number | 5R03AG081865-02 |
| Project ID | NIH-10844392 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced mild traumatic brain injuries, particularly those involved in contact sports or military service.
✕Less likely to help
Patients who have not experienced any form of traumatic brain injury may not receive benefit from this research.
What this research studies
This research explores the impact of mild traumatic brain injury (TBI) on cerebral amyloid angiopathy (CAA), a condition linked to Alzheimer's disease. Using a mouse model, the study aims to understand how mild TBIs may contribute to the accumulation of amyloid proteins in the brain's blood vessels, which could increase the risk of dementia. The approach involves examining the neurological changes following mild TBI and their potential long-term effects on brain health. By identifying these mechanisms, the research seeks to uncover new targets for intervention that could help prevent or mitigate dementia.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating dementia in individuals with a history of mild traumatic brain injuries.
How similar studies have gone: Previous research has shown that understanding the relationship between traumatic brain injuries and dementia can lead to significant advancements in treatment approaches, suggesting this study builds on established findings.
Where this research is happening
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Nova Southeastern University
Fort Lauderdale-Davie, United States Active
Researchers
- Principal investigator: Robison, Lisa Suzanne — Nova Southeastern University
- Study coordinator: Robison, Lisa Suzanne
Related research
Other NIH-funded projects on the same topics.
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Neurobehavioral effects of childhood brain injuries and addiction risk in twins
This grant studies how mild traumatic brain injury in childhood might influence behavior and the chance of developing addictive behaviors later in life, using twins to understand what’s due to injury versus other factors.
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This grant tests how people recover their balance after a mild brain injury and how targeted training could help prevent falls.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.