NIH-funded research NIH-funded research

How mild traumatic brain injury affects neurodegeneration in older adults

Official title: Contributions of mild traumatic brain injury to neurodegeneration due to chronic traumatic encephalopathy and alzheimer's disease

Funded at VA Boston Health Care System · NIH-10919799 · Data updated 2026-11-12

This study is looking at how mild traumatic brain injuries, which many Veterans experience, might affect memory and brain health over time, especially in relation to conditions like Alzheimer's disease, to help understand how these injuries can lead to cognitive decline.

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Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionVA Boston Health Care System
NIH-funded
Lab location1 site (Boston, United States)
Project startJuly 1, 2021
Project endJune 30, 2026
Funding year2024
NIH project number5IK2CX002065-04
Project IDNIH-10919799 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are Veterans aged 65 and older who have experienced mild traumatic brain injuries.

Less likely to help

Patients who have not experienced any form of traumatic brain injury may not benefit from this research.

What this research studies

This research investigates the impact of mild traumatic brain injury (mTBI) on neurodegeneration, particularly focusing on conditions like Alzheimer's disease and chronic traumatic encephalopathy. It aims to understand how single and repetitive mTBI, which is common among Veterans, contributes to cognitive decline and neurodegenerative changes. The study will assess behavioral and biomarker evidence of neurodegeneration, using recognition memory tests to differentiate between memory deficits caused by brain trauma and those related to neurodegenerative diseases. By examining these factors, the research seeks to clarify the relationship between mTBI and neurodegeneration in older adults.

Why it matters

Potential benefit: If successful, this research could lead to better understanding and potential interventions for neurodegenerative diseases in individuals with a history of mild traumatic brain injury.

How similar studies have gone: Previous research has shown promising results in understanding the links between traumatic brain injuries and neurodegenerative diseases, suggesting that this approach could yield valuable insights.

Where this research is happening

  • VA Boston Health Care System
    Boston, United States
    Active

Researchers

  • Principal investigator: Turk, Katherine W — VA Boston Health Care System
  • Study coordinator: Turk, Katherine W

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.