How mild traumatic brain injury affects neurodegeneration in older adults
Contributions of mild traumatic brain injury to neurodegeneration due to chronic traumatic encephalopathy and alzheimer's disease
This study is looking at how mild traumatic brain injuries, which many Veterans experience, might affect memory and brain health over time, especially in relation to conditions like Alzheimer's disease, to help understand how these injuries can lead to cognitive decline.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Boston Health Care System NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10919799 on NIH RePORTER |
What this research studies
This research investigates the impact of mild traumatic brain injury (mTBI) on neurodegeneration, particularly focusing on conditions like Alzheimer's disease and chronic traumatic encephalopathy. It aims to understand how single and repetitive mTBI, which is common among Veterans, contributes to cognitive decline and neurodegenerative changes. The study will assess behavioral and biomarker evidence of neurodegeneration, using recognition memory tests to differentiate between memory deficits caused by brain trauma and those related to neurodegenerative diseases. By examining these factors, the research seeks to clarify the relationship between mTBI and neurodegeneration in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are Veterans aged 65 and older who have experienced mild traumatic brain injuries.
Not a fit: Patients who have not experienced any form of traumatic brain injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential interventions for neurodegenerative diseases in individuals with a history of mild traumatic brain injury.
How similar studies have performed: Previous research has shown promising results in understanding the links between traumatic brain injuries and neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- VA Boston Health Care System — Boston, United States (Active)
Researchers
- Principal investigator: Turk, Katherine W — VA Boston Health Care System
- Study coordinator: Turk, Katherine W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.