Investigating brain changes related to cognitive status after mild traumatic brain injury
Official title: Diffusion MRI Model Parameter Estimation to Study Brain Microstructure as it Relates to Cognitive Status in Mild Traumatic Brain Injury
Funded at New York University School of Medicine · NIH-10896341 · Data updated 2026-11-12
This study is looking at how mild traumatic brain injuries can change the brain's structure and affect thinking skills, and it involves patients getting MRI scans to help us understand these changes better over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 15, 2021 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $641,786 |
| NIH project number | 5R01NS119767-04 |
| Project ID | NIH-10896341 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have recently experienced a mild traumatic brain injury and are experiencing cognitive symptoms.
✕Less likely to help
Patients with severe traumatic brain injuries or those with pre-existing neurological conditions may not benefit from this research.
What this research studies
This research focuses on understanding how mild traumatic brain injury (MTBI) affects brain microstructure and cognitive function. Using advanced diffusion MRI techniques, the study aims to identify changes in brain tissue that occur after an injury and how these changes relate to cognitive outcomes. By analyzing parameters such as axon integrity and cortical volume, researchers hope to provide insights into the long-term effects of MTBI on cognitive health. Patients may undergo MRI scans to help researchers gather data on brain structure and function over time.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatment strategies for individuals recovering from mild traumatic brain injury.
How similar studies have gone: Previous research has shown promise in using diffusion MRI techniques to study brain microstructure, indicating that this approach may yield valuable insights.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Lui, Yvonne W — New York University School of Medicine
- Study coordinator: Lui, Yvonne W
Related research
Other NIH-funded projects on the same topics.
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Mild Traumatic Brain Injury: A High-Tech Look Inside the Brain with Diffusion MRI
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Neurobehavioral effects of childhood brain injuries and addiction risk in twins
This grant studies how mild traumatic brain injury in childhood might influence behavior and the chance of developing addictive behaviors later in life, using twins to understand what’s due to injury versus other factors.
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Understanding and improving reactive balance after mild traumatic brain injury
This grant tests how people recover their balance after a mild brain injury and how targeted training could help prevent falls.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.