Recovery after mild traumatic brain injury in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective cohort will enroll 250 adults aged 65 and older treated for mild TBI at the R Adams Cowley Shock Trauma Center or affiliated University of Maryland hospitals. Participants will be enrolled within 72 hours of injury and followed at 2 weeks and at 3, 6, and 12 months to measure cognitive, physical, psychological, and sleep outcomes. The study will use clinical records, imaging when available, and standardized tests and questionnaires to map recovery trajectories. Researchers will analyze which baseline factors, such as age, comorbidities, and injury characteristics, are associated with better or worse recovery.

Why it matters

Who can join: the full rules

Inclusion Criteria

* Aged 65 years or older
* Treated for mild TBI (defined below) at the R Adams Cowley Shock Trauma Center (STC) or at one of six University of Maryland Affiliated Hospitals within 72 hours of injury
* Mild TBI was defined as:

  * Traumatically induced physiological disruption of brain function, as manifested by at least one of the following 1) loss of consciousness ≤30 minutes, post-traumatic amnesia \<24 hours, observed or self-reported transient confusion, disorientation, or impaired consciousness, or neurologic deficit as defined by a Glasgow Coma Scale (GCS) score of 13-14 on admission.
  * GCS of 15 with no other evidence of mild TBI was also accepted with positive computed tomography image.

Exclusion criteria

* Injury to any other body region resulting in an abbreviated injury scale (AIS) score \>2
* Anticipation that patient would not be ambulatory at 2-weeks post-injury
* History of dementia as determined by patient/proxy report or medical history
* Non-ambulatory pre-injury
* No available proxy
* Not English speaking
* Prisoners
* Live \>55 miles from the STC.

Where it's running

• University of Maryland, Baltimore
  Baltimore, Maryland, United States Recruiting

Study contacts

• Principal investigator: Jennifer Albrecht, PhD — University of Maryland
• Study coordinator: Jennifer Albrecht, PhD
• Email: jalbrecht@som.umaryland.edu
• Phone: 410-706-0071

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• TES HT100 screening for intracranial problems after mild head injury or new neurological symptoms

  This test checks if the TES HT100 can quickly and safely find intracranial problems in adults who come to the emergency department with mild head injury or new non‑traumatic neurological symptoms.

  Recruiting at 2 sites B&B srl · Castel Volturno, CE and 2 other locations · NCT07490418

• Two online brain-training programs to help emotional health after mild TBI

  This study tests two remote brain-training programs to see which better improves emotional health in adults with mild traumatic brain injury and alexithymia.

  Recruiting at 2 sites Hackensack Meridian Health · Indianapolis, Indiana and 2 other locations · NCT07436754

• Cognitive behavioral therapy for insomnia in people with mild traumatic brain injury

  This study will try cognitive behavioral therapy for insomnia (CBT-I) to see if it helps adults with mild traumatic brain injury sleep better and improve daily functioning.

  Recruiting University of Missouri-Columbia · Columbia, Missouri · NCT07385105

• Passive neurosensory reintegration training to help recovery after mild traumatic brain injury

  We will try a gentle multisensory therapy called passive neurosensory reintegration training (PNRT) to see if it helps adults with sub-acute or chronic mild traumatic brain injury recover neurosensory and cognitive symptoms.

  Recruiting University of Miami · Miami, Florida · NCT07356167

• Early Intervention for Adults with Ongoing Post-Concussion Symptoms after Mild TBI

  This study tests a package of physical/occupational therapy and telephonic psychoeducation to help adults recover after a mild traumatic brain injury.

  Recruiting University Medical Center Groningen · Groningen · NCT07341074

• Improving thinking after a concussion using gentle brain stimulation plus cognitive training

  This trial will test whether pairing a mild, non-invasive brain stimulation (tDCS) with cognitive training can help adults who still have thinking problems 3–12 months after a mild concussion.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07246993

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.