Improving memory symptoms after brain concussion

REhabilitation of MEMory Symptoms After BRain Concussion

This study is testing whether cognitive behavioral therapy or memory training can help adults who have ongoing memory problems after a concussion feel better.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 184 (estimated)
• Ages: 18 Years to 59 Years
• Sex: All
• Sponsor: University of British Columbia (other)
• Locations: 9 sites (Calgary, Alberta and 8 other locations)
• Trial ID: NCT06956417 on ClinicalTrials.gov

What this trial studies

This study aims to evaluate the effectiveness of cognitive behavioral therapy (CBT) and cognitive compensatory strategy training (CCST) in improving subjective memory functioning in adults who have persistent memory symptoms following a concussion. Participants will be randomly assigned to one of three groups: CBT, CCST, or a waitlist control. The study will utilize a multisite, three-armed randomized control trial design, ensuring that participants are blinded to the other treatment arms. The goal is to determine which intervention is most effective in addressing memory concerns after a concussion.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18-59 who have experienced a concussion within the last 6 to 36 months and are experiencing ongoing memory concerns.

Not a fit: Patients with comorbid psychiatric or neurological disorders or those whose memory symptoms can be fully explained by medication will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide effective therapeutic options for individuals suffering from persistent memory issues after a concussion.

How similar studies have performed: Previous studies have shown promise in using cognitive rehabilitation and CBT for memory improvement, suggesting that this approach may be effective.

Eligibility criteria

Inclusion Criteria:

1. Age 18-59
2. Concussion diagnosis confirmed with structured interview based on American Congress of Rehabilitation Medicine diagnostic criteria
3. Concussion occurred between 6 and 36 months before enrollment
4. Ongoing memory concerns
5. Fluent in English
6. Stable access to a computer, tablet, or smartphone with internet capability

Exclusion Criteria:

1. Fail performance validity testing
2. Comorbid psychiatric or neurological disorder or is taking a medication that could fully account for their memory symptoms

Where this trial is running

Calgary, Alberta and 8 other locations

• Calgary Brain Injury Program — Calgary, Alberta, Canada (RECRUITING)
• Fraser Health Acquired Brain Injury and Concussion Services — Langley, British Columbia, Canada (RECRUITING)
• G.F. Strong Adult Concussion Services — Vancouver, British Columbia, Canada (RECRUITING)
• Integrated Adult Concussion Program at Hamilton Health Sciences — Hamilton, Ontario, Canada (NOT_YET_RECRUITING)
• 360 Concussion Care Clinic — Ottawa, Ontario, Canada (NOT_YET_RECRUITING)
• Sunnybrook Traumatic Brain Injury Clinic — Toronto, Ontario, Canada (NOT_YET_RECRUITING)
• Head Injury Clinic at St. Michael's Hospital — Toronto, Ontario, Canada (NOT_YET_RECRUITING)
• Hull-Ellis Concussion and Research Clinic at University Health Network — Toronto, Ontario, Canada (NOT_YET_RECRUITING)
• Canadian Concussion Centre at Toronto Western Hospital — Toronto, Ontario, Canada (NOT_YET_RECRUITING)

Study contacts

• Principal investigator: Noah D Silverberg, PhD — University of British Columbia
• Study coordinator: Noah D Silverberg, PhD

Conditions: Concussion, Brain, Mild Traumatic Brain Injury, Functional cognitive disorder