Investigating how a specific protein affects brain cells after repeated mild injuries
Official title: The role of PPARγ in astrocyte pathobiology after exposure to repetitive mild traumatic brain injury
Funded at Roskamp Institute, INC. · NIH-10739968 · Data updated 2026-11-12
This study is looking at how a protein in brain cells reacts after repeated mild brain injuries, using mice to find out if these changes can help or hurt recovery, with the hope of discovering new treatments for people affected by such injuries.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Roskamp Institute, INC. NIH-funded |
| Lab location | 1 site (Sarasota, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $449,444 |
| NIH project number | 1R21AG080661-01A1 |
| Project ID | NIH-10739968 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced repetitive mild traumatic brain injuries, particularly athletes or those in contact sports.
✕Less likely to help
Patients who have not experienced any form of traumatic brain injury may not receive any benefit from this research.
What this research studies
This research focuses on understanding the role of a protein called PPARγ in brain cells known as astrocytes after they experience repetitive mild traumatic brain injuries (r-mTBI). The study uses a mouse model that mimics human brain injuries to explore how astrocytes change in response to these injuries and how these changes can either help or hinder brain recovery. By examining the cellular mechanisms involved, the research aims to identify potential new treatments to mitigate long-term neurological damage caused by r-mTBI.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that help protect brain function and improve recovery for individuals who have suffered repetitive mild traumatic brain injuries.
How similar studies have gone: Other research has shown promise in understanding the role of astrocytes in brain injury, suggesting that this approach could yield valuable insights and potential breakthroughs.
Where this research is happening
-
Roskamp Institute, INC.
Sarasota, United States Active
Researchers
- Principal investigator: Ojo, Joseph O — Roskamp Institute, INC.
- Study coordinator: Ojo, Joseph O
Related research
Other NIH-funded projects on the same topics.
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Mild Traumatic Brain Injury: A High-Tech Look Inside the Brain with Diffusion MRI
Researchers are using advanced brain imaging to find biological clues in people who have mild traumatic brain injuries.
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How neuromodulation may help headaches after a mild brain injury
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A research team is studying why some people develop long-lasting pain after a mild head injury and how brain inflammation contributes to it.
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Retraining brain pathways to boost thinking after a mild head injury
A clinical trial tests a brain-training program to improve thinking and memory in people who have had a mild traumatic brain injury (mTBI).
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Neurobehavioral effects of childhood brain injuries and addiction risk in twins
This grant studies how mild traumatic brain injury in childhood might influence behavior and the chance of developing addictive behaviors later in life, using twins to understand what’s due to injury versus other factors.
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Understanding and improving reactive balance after mild traumatic brain injury
This grant tests how people recover their balance after a mild brain injury and how targeted training could help prevent falls.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.