Gout, inflammation, and metabolic health in French Polynesia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational, population-based effort to map the genetic and molecular landscape of hyperuricaemia, gout, and related metabolic and inflammatory traits in French Polynesia. Investigators will enroll adults of Polynesian ancestry from general practice visits, a rheumatology clinic cohort, people with tophaceous gout, recent gout attacks, and a 2021 TOPATA follow-up group, collecting blood and urine samples and clinical/anthropometric data. Laboratory analyses will include serum urate measurements, molecular assays and genetic analyses to look for variants and biomarkers linked to MSU crystal deposition and inflammatory response. The project aims to relate molecular and genetic findings to clinical patterns and cardiometabolic comorbidities in a population with very high hyperuricaemia prevalence.

Why it matters

Who can join: the full rules

Inclusion Criteria:

All participants:

* Age between 18 and 75 years old inclusive
* Signature of informed consent
* Fasting for the collection of biological samples
* Declared Polynesian ancestry
* Affiliated to a social security scheme

General population group :

* Not having participated to the 2021 TOPATA study
* Visiting a general practitioner (for whatever reason)

Gout Group :

* Managed at the rheumatology clinic of the Taaone Hospital Centre (CHT) in Papeete by Dr Baptiste Gérard.

Tophaceous gout sub-group:

* Present with tophaceous gout.

Gout crisis subgroup:

* Be within 48 hours of the onset of a gout attack
* Agree to return 1 week after inclusion for the second blood and urine sample.

  2021 follow-up group:
* To have been included in the TOPATA study in 2021
* Have taken the genetic and biological samples that generated the genetic and serum urate data for the 2021 study
* Have hyperuricaemia without signs of gout OR without hyperuricaemia or gout at the time of inclusion in TOPATA

Exclusion Criteria:

All participants :

* Refusal or inability to understand or give consent
* Physical inability to follow and respect the protocol
* 1st degree relative\*,
* Person under guardianship or trusteeship
* Pregnant or breast-feeding woman

  \* If several relatives from the same household are eligible to participate, only one person may be included in the study. The choice is left to the discretion of the investigator or the first person met. However, both members of a couple (e.g. husband and wife) may participate.
* General population group :
* Unable to return for sampling if required.
* Gout group :
* Person wearing a knee prosthesis
* People suffering from other inflammatory rheumatic diseases

Where it's running

• Medical Office Dr Antoine Scuiller
  Faa'a, French Polynesia Recruiting
• Medical Office Dr Cedric Gueguen
  Papeete, French Polynesia Recruiting
• Medical Office Dr Voradeth Nouanesengsy
  Papeete, French Polynesia Recruiting
• Medical Office Dr Nanethida Nouanesengsy
  Pirae, French Polynesia Recruiting
• Medical Office Dr Raphael Habib
  Pirae, French Polynesia Recruiting
• CH de Polynesie Française Papeete
  Pirae, French Polynesia Not yet recruiting

Study contacts

• Principal investigator: Tristan Pascart, Professor — Ghicl
• Study coordinator: Marie De Solere
• Email: desolere.marie@ghicl.net
• Phone: +33 3 20 22 59 31

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.