HIIT versus time-restricted eating to lower type 2 diabetes risk in adolescents and young adults
Differential Effects of HIIT vs. TRE on Type 2 Diabetes Risk in Youth and Younger Adults
This project will test whether 4 weeks of high-intensity interval training or time-restricted eating improves heart and metabolic health in adolescents and young adults with overweight or obesity.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 14 Years to 30 Years |
| Sex | All |
| Sponsor | Syracuse University Academic / other |
| Drugs / interventions | Prednisone |
| Locations | 1 site (Syracuse, New York) |
| Trial ID | NCT07215533 on ClinicalTrials.gov |
What this trial studies
This randomized controlled trial enrolls adolescents (14–17 years with BMI percentile ≥85th) and young adults (18–30 years with BMI ≥25 kg/m2) with overweight or obesity and randomly assigns them to a 4-week high-intensity interval training (HIIT) program or a time-restricted eating (TRE) schedule. The primary outcomes are changes in cardiometabolic biomarkers measured before and after the intervention, such as insulin sensitivity, blood lipids, and other metabolic indicators. Participants with major chronic medical conditions or on excluded medications are not eligible, and interventions are delivered at Syracuse University with close monitoring. The design focuses on short-term physiological responses to lifestyle changes that are feasible for adolescents and young adults.
Who should consider this trial
Good fit: Ideal candidates are 14–17 year-olds with sex- and race-specific BMI percentile ≥85th or 18–30 year-olds with BMI ≥25 kg/m2 who are otherwise healthy and not taking excluded medications.
Not a fit: Patients with existing chronic diseases (including diagnosed diabetes), those on excluded cardiovascular, endocrine, or psychotropic medications, or those with implanted devices like a pacemaker are unlikely to qualify or benefit from this protocol.
Why it matters
Potential benefit: If successful, the interventions could lead to improved insulin sensitivity and other cardiometabolic markers that lower short-term risk factors for type 2 diabetes in youth with overweight or obesity.
How similar studies have performed: Prior research has shown that HIIT and TRE can each improve metabolic markers in adults, but short-term randomized comparisons in adolescents and young adults are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adolescents (age 14-17 years old with sex- and race-specific BMI percentile ≥85th) and young adults with overweight and obesity (age 18 to 30 years old with BMI ≥25 kg/m2) Exclusion Criteria: * Chronic medical conditions: heart disease, arrhythmias, diabetes, thyroid disease, bleeding disorder, history of pulmonary disease, hypertension, hepatorenal disease, musculoskeletal disorder, neuromuscular/neurological disease, autoimmune disease, cancer, peptic ulcers, anemia, or chronic infection (HIV). * Have taken any heart, pulmonary, thyroid, anti-hyperlipidemic, hypoglycemic, anti- hypertensive, endocrinologic (e.g., thyroid, insulin, etc.), emotional/psychotropic (e.g., Prednisone, Ritalin, Adderall), neuromuscular/neurological, or androgenic medications (anabolic steroids). * Have a pacemaker.
Where this trial is running
Syracuse, New York
- Syracuse University — Syracuse, New York, United States (Recruiting)
Study contacts
- Study coordinator: Wonhee Cho, MS, PhD Candidate
- Email: wcho02@syr.edu
- Phone: +16267270270
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.