Evaluation of cardiometabolic factors in heart failure patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort study investigates the impact of systemic and local cardiometabolic risk factors on cardiac remodeling and clinical outcomes in heart failure patients. It combines retrospective clinical data from the past decade with a 5-year prospective follow-up, examining various heart failure phenotypes including HFrEF, HFmrEF, HFpEF, and HFimpEF. The study analyzes metabolic factors such as blood lipid profiles and insulin resistance, alongside localized factors like epicardial and perivascular adipose tissue, to understand their associations with cardiac function and adverse cardiovascular events.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥ 18 years
2. Chronic HF (NYHA II\~IV), including:

   * HFrEF (HF with reduced ejection fraction): ① HF symptoms±signs ; ② LVEF≤40%.
   * HFimpEF (HF with improved ejection fraction): ① HF symptoms±signs; ② previous LVEF ≤ 40% and a follow-up measurement of LVEF \>40%.
   * HFmrEF (HF with mildly reduced ejection fraction): ① HF symptoms±signs; ② LVEF 41%\~49%.
   * HFpEF (HF with preserved ejection fraction): ① HF symptoms±signs; ② LVEF ≥50%; ③ objective evidence of cardiac structural and/or functional abnormalities consistent with the presence of LV diastolic dysfunction/raised LV filling pressures, including raised natriuretic peptide.

Exclusion Criteria:

1. Estimated survival ≤ 1 year.
2. Pregnant or lactation, or have the intention to give birth within one year.
3. Poor compliance, unable to follow-up.
4. Mental or physical status not allowing written informed consent.
5. Unwillingness to give informed consent.

Where it's running

• Ruijin Hospital, Shanghai Jiaotong University School of Medicine
  Shanghai, China Recruiting

Study contacts

• Principal investigator: Ruiyan Zhang, M.D., Ph.D. — Ruijin Hospital
• Study coordinator: Chendie Yang, M.D., Ph.D.
• Email: yangcd1029@163.com
• Phone: 0086-21-64370045-671503

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.