Using MRI to study brain differences in metabolic diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to utilize magnetic resonance imaging (MRI) to explore structural, functional, and metabolic brain differences in individuals with metabolic diseases compared to healthy controls. The research will track the clinical and imaging histories of participants over time, focusing on how changes in whole-body metabolism and body weight may influence brain characteristics. By correlating these brain changes with body composition metrics, the study seeks to identify distinct imaging features associated with metabolic conditions. The study is conducted at Ulm University Hospital and includes adults aged 18 and older who can provide informed consent.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* patients with metabolic diseases OR
* healthy control participants without metabolic diseases
* written consent

Exclusion Criteria:

* History of traumatic brain injuries
* preterm birth (≤34th week of pregnancy) of the study participant
* history of brain surgery
* structural brain changes (e.g., tumors, congenital abnormalities, etc.)
* neurological developmental disorders (e.g., autism spectrum disorders, learning disabilities, intellectual disability)
* epilepsy,
* drug addiction
* other severe neurological or severe psychiatric disorders (e.g., schizophrenia
* pregnancy
* acute clinically relevant inflammatory diseases
* acute systemic or local infections
* severe or etiologically unclear diseases depending on the principle investigators judgement
* pre-existing intellectual impairment
* significant limitations in language comprehension
* absence of written consent
* general exclusion criteria for MRI imaging (e.g., pacemaker systems, neurostimulators, cochlear implants)

Where it's running

• University Hospital Ulm
  Ulm, Germany Recruiting

Study contacts

• Study coordinator: Martin Heni, Prof. Dr. med.
• Email: martin.heni@uniklinik-ulm.de
• Phone: +4973150044505

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Registering medical data and care outcomes for ALS, SMA, and other motor disorders

  This registry slowly collects routine-care information from adults with ALS, SMA, or other motor disorders to see how they’re treated and how care affects outcomes.

  Recruiting Ambulanzpartner Soziotechnologie APST GmbH · Berlin, State of Berlin · NCT07900672

• Myokines in metabolic and endocrine diseases linked to sarcopenia

  This study tests whether myokines can serve as biomarkers or drivers of sarcopenia and sarcopenic obesity in people with metabolic or endocrine diseases.

  Recruiting Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Woluwe-Saint-Pierre - Sint-Pieters-Woluwe · NCT07703683

• AMX0035 in adults with Type 1 Diabetes

  This study tests whether 24 weeks of the oral medication AMX0035 help improves metabolic health in adults with Type 1 Diabetes compared with a placebo.

  Recruiting Phase 2 University of Washington · Seattle, Washington and 1 other locations · NCT07699380

• A lifetime registry and imaging database for people with heart, kidney, and metabolic conditions

  This project will see if creating a long-term clinical and imaging database for adults with heart, kidney, or metabolic conditions can improve prediction of outcomes and guide care.

  Recruiting First Affiliated Hospital of Fujian Medical University · Fuzhou, Fujian · NCT07547098

• Early pregnancy lifestyle patterns and glucose changes in a TOFFFY sub-study

  This study tests whether daily patterns like sleep, activity, and meal timing in early pregnancy affect glucose levels and the risk of gestational diabetes, using CGM and wearable data in pregnant women in Singapore.

  Recruiting KK Women's and Children's Hospital · Singapore, Singapore · NCT07534670

• Measuring how well patients follow daily oral medicines in Necker’s inherited metabolic diseases department

  This project will measure how well children, adolescents, and young adults with inherited metabolic diseases at Necker follow their daily oral medicines to see if a medication-education workshop is needed.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07356557

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.