NIH-funded research R01 grant

Bionic Breast: Restoring touch and reducing pain after mastectomy

Official title: Bionic Breast Project: A Neuroprosthesis to Restore Touch Sensation and Reduce Chronic Pain After Mastectomy

Funded at University of Chicago · NIH-11394424 · Data updated 2026-11-12

A small study tests a neural prosthesis to bring back touch and ease chronic pain for women who have had a mastectomy.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Chicago
NIH-funded
Lab location1 site (Chicago, United States)
Project startAugust 1, 2023
Project endJuly 31, 2028
Funding year2026
Award (this year)$783,980
NIH project number5R01CA281301-04
Project IDNIH-11394424 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates are women who recently underwent mastectomy and reconstruction and are eligible for implantation of the BBD.

Less likely to help

Patients with contraindications to surgery or those unable or unwilling to undergo implant anesthesia may not benefit.

What this research studies

This project aims to deliver a small implant called the Bionic Breast Device to women who recently had mastectomy and reconstruction. By stimulating intercostal nerves and using a stretchable sensor on the breast area, the device hopes to recreate a natural touch sensation. The study will carefully implant cuff electrodes and monitor sensory changes and pain levels to understand how patients perceive touch after surgery. It builds on successes from limb prosthetics that restore touch by electrical stimulation, adapted for the breast region.

Why it matters

Potential benefit: If successful, the device could restore a natural sense of touch and reduce chronic neuropathic pain for mastectomy patients.

How similar studies have gone: Prior neural prosthetics have restored touch in limbs; this study extends the concept to the breast with a novel sensor.

Where this research is happening

  • University of Chicago
    Chicago, United States
    Active

Researchers

  • Principal investigator: Lindau, Stacy Tessler — University of Chicago
  • Study coordinator: Lindau, Stacy Tessler

Related research

Other NIH-funded projects on the same topics.

  • Bionic breast neuroprosthesis to restore touch and reduce pain after mastectomy

    This trial offers a small implant that senses touch on the reconstructed breast and stimulates chest nerves to bring back feeling and ease chronic pain for women after mastectomy.

    NIH research University of Chicago · Chicago, United States · NIH-11140546

  • A device to restore touch sensation and reduce pain after breast surgery

    This study is testing a new device called the Bionic Breast Device that aims to help women who have had a mastectomy by restoring touch sensations and reducing chronic pain, so if you're a breast cancer survivor looking for ways to improve your quality of life, this could be for you!

    NIH research University of Chicago · Chicago, United States · NIH-10894812

  • Motor cortex tricks to ease chronic pain

    A study in rodents and people tests whether non-invasive brain stimulation of the motor cortex can reduce chronic pain and how best to target it.

    NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11621209

  • Human pain center study to map normal and migraine-trigeminal neurons

    A large NIH-funded project will map and study the human trigeminal neurons involved in migraines to understand what changes in these cells during headache conditions.

    NIH research University of Pennsylvania · Philadelphia, United States · NIH-11615140

  • Understanding human pain neurons to improve migraine care

    Researchers are studying human pain-sensing neurons to uncover what makes migraine start and persist, with the goal of better treatments for people who experience migraines.

    NIH research University of Pennsylvania · Philadelphia, United States · NIH-11615139

  • Whole Person Pain Algorithm to personalize chronic pain care

    A new, evidence-based model helps explain why chronic low back pain affects people differently and could guide personalized diagnosis and treatment.

    NIH research University of Florida · Gainesville, United States · NIH-11609318

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.