Repeat Sentinel Lymph Node Biopsy for Breast Cancer Recurrence

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of repeat sentinel lymph node biopsy (reSLNB) in patients experiencing ipsilateral breast tumor recurrence after initial treatment. It aims to determine whether this procedure can provide valuable information regarding axillary lymph node status, which is crucial for guiding further treatment decisions. The study focuses on patients who have previously undergone partial mastectomy and sentinel lymph node biopsy, and who are clinically assessed to be axillary lymph node negative. By evaluating the outcomes of reSLNB, the study seeks to improve treatment strategies for breast cancer recurrence.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age over 19 years old
2. Patients who are expected to undergo surgery under the diagnosis of ipsilateral breast tumor recurrence(histologically confirmed in situ disease or invasive disease)
3. Patients who had partial mastectomy and sentinel lymph node biopsy for prior operation for the initially diagnosed breast cancer
4. Patients considered to be axillary lymph node negative from clinical findings
5. Patients who understand and willingly participate in the study

Exclusion Criteria:

1. Patients with recurrence in other regions. (e.g. ipsilateral axillary lymph node, supraclavicular lymph node, internal mammary lymph node, etc.)
2. Patients who are not eligible to perform SLNB
3. Patients who received mastectomy or axillary lymph node dissection for prior operation
4. Patients who experienced recurrence within a year from the primary operation
5. Patientes who are known to have axillary lymph node metastasis before the secondary operation, histologically confirmed from tissue biopsy or cytology
6. Patients with systemic recurrence
7. Patients with inflammatory breast cancer

5\) Pregnant and lactating patients

Where it's running

• Gangnam Severance Hospital, Yonsei University College of Medicine
  Seoul, South Korea Recruiting

Study contacts

• Principal investigator: Joon Jeong — Gangnam Severance Hospital, Yonsei University College of Medicine
• Study coordinator: Soong June Bae, M.D.
• Email: mission815815@yuhs.ac
• Phone: 82-2-2019-4401

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.