Condition

Malignancy clinical trials and research

• 14Clinical trials
• 57NIH research projects
• 10Countries

Newest Malignancy clinical trials

All recruiting trials (14)

• Sedation Methods in PTBD: How Two Regimens Compare for Quality and Recovery

  This study tests two sedation plans (propofol with remifentanil vs propofol with ketamine) to see which helps patients recover faster after PTBD while staying comfortable and safe.

  Recruiting Ankara City Hospital Bilkent · Ankara, Ankara · NCT07640243

• Chest wall reconstruction using twisted stainless steel wires versus PMMA bone cement

  This project will test whether twisted stainless steel wires or PMMA bone cement gives better outcomes for adults needing chest wall reconstruction after tumor- or infection-related resections.

  Recruiting University of Health Sciences Lahore · Lahore, Punjab Province · NCT07338006

• Do repeated hyperbaric oxygen sessions increase DNA damage after radiotherapy?

  This tests whether repeated hyperbaric oxygen therapy sessions cause more DNA damage in adults who are receiving HBOT after prior radiotherapy or for related complications.

  Recruiting University Hospital, Angers · Angers · NCT06999785

• Capmatinib treatment for adults with cancers having MET gene changes

  This study is testing if capmatinib, a drug for lung cancer, can help adults with different types of cancers that have changes in the MET gene.

  Recruiting at 16 sites Phase 2/3 Cancer Research UK · Belfast and 16 other locations · NCT06988475

• Informatics-assisted detection of immune-related side effects to improve biorepository enrollment

  This project tests whether an automated system that reads electronic health records can help identify cancer patients on immunotherapy who are having immune-related side effects so they can be enrolled in a biorepository.

  Recruiting at 2 sites Phase 1/2 Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT06789601

• Imaging method for digestive system cancer using targeted PET scans

  This study is testing a new type of PET scan to see if it can better help doctors find and diagnose cancers in the digestive system.

  Recruiting RenJi Hospital · Shanghai, Shanghai Municipality · NCT06715839

• Two thin Percuflex polyurethane stents versus one larger 8Fr silicone stent for malignant ureteral obstruction

  The trial will try placing two 6Fr Percuflex polyurethane stents side-by-side versus a single large 8Fr silicone stent in people with malignant ureteral obstruction to see which approach fails less often and how they affect comfort, quality of life, and survival.

  Recruiting at 2 sites Rabin Medical Center · Petah Tikva and 1 other locations · NCT05992363

• Entrectinib treatment for patients with ROS1-positive cancers

  This study is testing if the drug entrectinib can help people with different types of cancers that have a ROS1 gene fusion, including adults and kids, to see if it works better than what’s currently available.

  Recruiting at 24 sites Phase 2/3 Cancer Research UK · Belfast and 26 other locations · NCT05770544

• Using atezolizumab to treat cancers with high mutation rates or specific genetic deficiencies

  This study is testing if atezolizumab can help treat adults and kids with certain types of cancers that have a lot of genetic changes or specific genetic issues.

  Recruiting at 23 sites Phase 2/3 Cancer Research UK · Belfast and 26 other locations · NCT05770102

• Using 18F-PSMA PET/CT imaging for detecting prostate-specific tumors

  This study is testing a new type of imaging to see if it can better find prostate-specific tumors in patients with prostate cancer and other related cancers.

  Recruiting Phase 2 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Chaoyang · NCT05761366

• Identifying risk factors for heart disease and cancer in Koreans

  This study is trying to find out what risk factors and health habits can lead to heart disease and cancer in Koreans by following 510,000 people over 10 years.

  Recruiting Ulsan University Hospital · Ulsan · NCT05389956

• Allogeneic CAR T-cell therapy for advanced cancers

  This study is testing a new type of immune cell therapy for people with advanced cancers to see if it can safely target and attack their tumors better than traditional treatments.

  Recruiting Phase 1 CytoMed Therapeutics Pte Ltd · Singapore · NCT05302037

• A comprehensive database for cancer patient genomic and clinical data

  This study is creating a detailed database of cancer patients' genetic and health information to see if it can help improve treatment outcomes for different types of cancer.

  Recruiting BostonGene · Waltham, Massachusetts · NCT04991922

• Comparing Propofol and Sevoflurane for Children's Tumor Surgery

  This study is testing whether two types of anesthesia, propofol and sevoflurane, can affect the health and recovery of children having surgery for tumors.

  Recruiting Phase 4 Hong Kong Children's Hospital · Hong Kong · NCT04475705

NIH-funded research (newest 40 of 57)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Detecting cancer risk and treatment response in NF1 nerve tumors using cfDNA markers

  A doctor-led study will test blood-based DNA markers to detect when NF1-related nerve tumors become malignant and to monitor how well treatment is working.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11452312

• Epigenetic Basis for Controlling Aggressive IDH-Mutant Gliomas

  Aims to understand and shape the epigenetic changes in IDH-mutant brain tumors to restrain their growth, which could lead to new, targeted treatment options for patients.

  NIH research State University New York Stony Brook · Stony Brook, United States · NIH-11449546

• US–East Africa center to prevent and detect virus-linked cancers in people with HIV

  This program builds a US–East Africa research network to train local investigators and improve prevention, earlier detection, and faster connection to care for virus-related cancers in people with HIV.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11410166

• U.S.–East Africa program to prevent, detect early, and link people with HIV-related cancers to care

  This program brings U.S. and East African teams together to help people with HIV by improving prevention, earlier detection, and faster connection to care for cancers linked to the virus.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11410161

• U.S.–East Africa center to prevent and find HIV-related cancers and speed connection to care

  This program builds a U.S.–East Africa team to improve prevention, earlier detection, and faster linkage to care for people with HIV at risk for cervical cancer and Kaposi’s sarcoma.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11410157

• Boosting TET Activity to Help Treat AML with Vitamin C

  Vitamin C may help people with a type of blood cancer (AML) by boosting a natural anti-cancer pathway, potentially improving outcomes for adults with this disease.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11398136

• Tissue tension and cancer: how stiff tissues drive cancer growth and spread

  This NIH grant explores how stiff tissue environments and mechanical forces inside the body may promote cancer growth, aggression, and spread, with the goal of finding biomarkers and new drug targets that could help patients.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11392427

• ATM's role in stopping lymphoid cancers

  A researcher at Columbia is studying how ATM helps prevent lymphoid cancers and what goes wrong when ATM is mutated.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11387555

• Myeloid Cancer Gene Variant Curation Expert Panel

  A patient-facing group creates and shares trusted rules for interpreting genetic variants that raise the risk of blood cancers, helping families understand their test results.

  NIH research Northwestern University · Chicago, United States · NIH-11384370

• Multisite rollout to help Hispanic kids join cancer trials

  A nationwide study to boost enrollment of Hispanic children with cancer into clinical trials by using trained parent navigators who speak the language and understand health literacy.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11374939

• Multispectral imaging to catch bile duct cancer early

  A new imaging approach during routine ERCP procedures aims to spot early bile duct cancer before it becomes deadly.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11348912

• Epigenetic Test for Severe Spermatogenic Failure and Cancer Risks

  A new epigenetic test aims to help men with severe infertility understand their cancer risk and guide future treatments.

  NIH research Inherent Biosciences, INC. · Salt Lake City, UNITED STATES · NIH-11314862

• Why people with sickle cell disease have higher risk of blood cancers

  This project is checking if oxidative DNA damage in blood stem cells explains the higher risk of blood cancers after transplants or gene therapy in adults with sickle cell disease.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11310848

• Chromatin-remodeling complexes and their role in human cancers

  Researchers are looking at how mutations in chromatin-remodeling complexes cause different cancers so future treatments can target those changes for patients.

  NIH research Stanford University · Stanford, United States · NIH-11306595

• What triggers cancer in BRCA1-linked breasts

  This work looks for early cell changes that lead to breast cancer in people with harmful BRCA1 mutations so safer prevention options can be developed.

  NIH research University of California-Irvine · Irvine, United States · NIH-11306068

• Targeting LSD1 to prevent early oral cancers from getting worse

  Seeing if blocking a protein called LSD1 can stop precancerous mouth lesions and early oral cancers from becoming invasive.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11301858

• Noninvasive mapping to predict liver cancer aggressiveness

  Using an advanced MRI method to map tumor metabolism in people with liver cancer to better predict which tumors will behave aggressively.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11263728

• Safer antibiotic choices for people with blood cancers and reported penicillin/beta‑lactam allergy

  This project helps people with blood cancers who report a penicillin or related antibiotic allergy learn whether they can safely use those drugs so they can get the most effective antibiotics.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11261247

• Faulty DNA rearrangements in B cells that start B‑cell (lymphoid) cancers

  This research looks at how abnormal DNA breaks in developing B cells may lead to B‑cell cancers, to help people with or at risk for lymphoid malignancies.

  NIH research University of California-Irvine · Irvine, United States · NIH-11258890

• Drug-targetable epigenetic changes driving aggressive neuroblastoma

  Researchers are looking at whether drugs that change how genes are packaged (epigenetic drugs) can block aggressive neuroblastoma in children.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11258053

• Extra 17q chromosome and aggressive neuroblastoma

  Researchers are looking at how an extra copy of chromosome 17q makes neuroblastoma tumors grow faster and resist chemotherapy in children.

  NIH research Children's Hospital of Los Angeles · Los Angeles, United States · NIH-11252342

• Mapping early lung changes that can lead to lung cancer

  This project uses low-dose CT scans and tumor DNA and immune markers to find patterns that predict which small lung nodules are likely to be dangerous for people at risk of lung cancer, especially veterans.

  NIH research VA Greater Los Angeles Healthcare System · Los Angeles, United States · NIH-11212789

• Evaluating cancer treatments for people living with HIV

  This study is looking at better ways to treat and prevent cancer for people living with HIV, and it offers a chance for patients to join clinical trials that could help improve their care.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11191802

• Eosinophils and esophageal cancer: uncovering a new protective role

  A study exploring whether a type of immune cell called eosinophils can help prevent esophageal cancer from developing or progressing in people at risk.

  NIH research Veterans Health Administration · Nashville, United States · NIH-11181415

• How tissue stiffness and tension drive cancer and spread

  This project looks at how stiff or tense tissues can make normal cells become cancerous and help tumors spread, with a focus on breast and other solid cancers.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11180066

• How the tumor neighborhood affects low-grade glioma turning into a more dangerous cancer

  Researchers will map cells and molecules inside low-grade glioma tumors to find signs that predict which tumors in people may become malignant.

  NIH research California Institute of Technology · Pasadena, United States · NIH-11174518

• How the ATM protein prevents lymphoid cancers

  Researchers are studying how changes in the ATM gene affect the development and treatment of lymphoid cancers, especially for people with ATM mutations or Ataxia‑Telangiectasia.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11164715

• Boosting TET enzymes with vitamin C for acute myeloid leukemia

  This project explores whether giving vitamin C can boost a natural enzyme and help adults with TET2‑mutant acute myeloid leukemia.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11161573

• Helping Hispanic children with cancer join clinical trials through parent support

  This project helps parents of Hispanic children with cancer understand clinical trials better, so more children can join these important treatment opportunities.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11128569

• Genetic variant review team for myeloid blood cancers

  Experts are reviewing inherited genetic changes that raise the risk of myeloid blood cancers so patients and families get clearer test results and care guidance.

  NIH research Northwestern University · Chicago, United States · NIH-11124044

• Better tools for finding bile duct cancer early

  This project is developing a new way to find bile duct cancer at its earliest stages, when it is most treatable.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11123497

• How IMPDH2-driven GTP metabolism makes glioblastoma aggressive and treatment-resistant

  Researchers are studying a protein called IMPDH2 that helps glioblastoma cells make GTP, to try to stop tumor growth and make treatments work better for people with aggressive brain tumors.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11122305

• Improving prevention and early care for HIV-related cancers in East Africa

  This program brings U.S. and East African teams together to prevent, find earlier, and speed access to treatment for people with HIV who face virus-related cancers like cervical cancer and Kaposi's sarcoma.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11112369

• Understanding why sickle cell disease increases the risk of blood cancers.

  This study is looking at why adults with sickle cell disease might have a higher chance of developing blood cancers, and it aims to find out how stress on their cells and DNA damage could play a role, which could help improve treatments for people with sickle cell disease.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11110191

• Improving antibiotic choices for cancer patients with reported penicillin allergies

  This study is looking to help patients with blood cancers who are at risk for infections by finding better ways to choose antibiotics, especially for those who might have been wrongly labeled as allergic to certain medications, so they can receive safer and more effective treatments.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11077256

• Investigating early changes in colon adenomas that may lead to colorectal cancer

  This study is looking at early signs of colon problems, called adenomas, that can lead to colorectal cancer, and it aims to find out what changes in the body might help us catch these issues early and prevent cancer from developing.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11074926

• Mapping tumor biology in liver cancer to predict malignancy

  This study is looking at a new MRI technique to help doctors better spot and understand liver cancer, so they can create more personalized treatment plans for patients with this condition.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11053561

• Understanding how chromosome 17q affects neuroblastoma cancer severity

  This study is looking at how a specific genetic change on chromosome 17q affects neuroblastoma, a type of cancer that often affects children, to help understand why some tumors are harder to treat and to find new ways to improve care for young patients.

  NIH research Children's Hospital of Los Angeles · Los Angeles, United States · NIH-11051013

• Investigating how certain genetic factors influence neuroblastoma in children

  This study is looking at how certain genes make high-risk neuroblastoma, a tough childhood cancer, harder to treat, with the hope of finding better therapies for kids who need more options.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11050940

• How faulty DNA repair in B cells can lead to blood cancers

  This study is looking at how certain changes in DNA can lead to blood cancers in B cells, and it's for patients who want to understand more about their condition and how new treatments might be developed to help them.

  NIH research University of California-Irvine · Irvine, United States · NIH-11034125

Related topics

Quick answers

How many Malignancy clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United Kingdom (3 trials), China (2 trials), United States (2 trials), Hong Kong (1 trial), Israel (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2/3: 3, Phase 4: 1, Phase 2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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