Understanding how chromosome 17q affects neuroblastoma cancer severity
Define the role of chromosome 17q gain in neuroblastoma malignancy
This study is looking at how a specific genetic change on chromosome 17q affects neuroblastoma, a type of cancer that often affects children, to help understand why some tumors are harder to treat and to find new ways to improve care for young patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospital of Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11051013 on NIH RePORTER |
What this research studies
This research investigates the role of chromosome 17q gain in neuroblastoma, a common pediatric cancer. By using a human stem cell model, researchers will explore how genetic changes influence tumor development and response to treatment. The study aims to clarify why tumors with this chromosome alteration are associated with worse outcomes. Through advanced techniques, the research seeks to identify potential therapeutic targets that could improve patient care.
Who could benefit from this research
Good fit: Ideal candidates for this research are pediatric patients diagnosed with neuroblastoma, particularly those exhibiting chromosome 17q gain.
Not a fit: Patients with neuroblastoma who do not have chromosome 17q gain may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatment strategies for neuroblastoma patients with chromosome 17q gain.
How similar studies have performed: While the role of chromosome 17q in neuroblastoma has been recognized, this specific approach using human stem cell models is relatively novel and has not been extensively tested.
Where this research is happening
Los Angeles, United States
- Children's Hospital of Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Huang, Miller — Children's Hospital of Los Angeles
- Study coordinator: Huang, Miller
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.