Understanding how chromosome 17q affects neuroblastoma cancer severity
Official title: Define the role of chromosome 17q gain in neuroblastoma malignancy
Funded at Children's Hospital of Los Angeles · NIH-11051013 · Data updated 2026-11-12
This study is looking at how a specific genetic change on chromosome 17q affects neuroblastoma, a type of cancer that often affects children, to help understand why some tumors are harder to treat and to find new ways to improve care for young patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospital of Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $562,869 |
| NIH project number | 1R01CA289964-01A1 |
| Project ID | NIH-11051013 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pediatric patients diagnosed with neuroblastoma, particularly those exhibiting chromosome 17q gain.
✕Less likely to help
Patients with neuroblastoma who do not have chromosome 17q gain may not benefit directly from this research.
What this research studies
This research investigates the role of chromosome 17q gain in neuroblastoma, a common pediatric cancer. By using a human stem cell model, researchers will explore how genetic changes influence tumor development and response to treatment. The study aims to clarify why tumors with this chromosome alteration are associated with worse outcomes. Through advanced techniques, the research seeks to identify potential therapeutic targets that could improve patient care.
Why it matters
Potential benefit: If successful, this research could lead to better treatment strategies for neuroblastoma patients with chromosome 17q gain.
How similar studies have gone: While the role of chromosome 17q in neuroblastoma has been recognized, this specific approach using human stem cell models is relatively novel and has not been extensively tested.
Where this research is happening
-
Children's Hospital of Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Huang, Miller — Children's Hospital of Los Angeles
- Study coordinator: Huang, Miller
Related research
Other NIH-funded projects on the same topics.
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Drug-targetable epigenetic changes driving aggressive neuroblastoma
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Extra 17q chromosome and aggressive neuroblastoma
Researchers are looking at how an extra copy of chromosome 17q makes neuroblastoma tumors grow faster and resist chemotherapy in children.
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Investigating how certain genetic factors influence neuroblastoma in children
This study is looking at how certain genes make high-risk neuroblastoma, a tough childhood cancer, harder to treat, with the hope of finding better therapies for kids who need more options.
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Detecting cancer risk and treatment response in NF1 nerve tumors using cfDNA markers
A doctor-led study will test blood-based DNA markers to detect when NF1-related nerve tumors become malignant and to monitor how well treatment is working.
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Epigenetic Basis for Controlling Aggressive IDH-Mutant Gliomas
Aims to understand and shape the epigenetic changes in IDH-mutant brain tumors to restrain their growth, which could lead to new, targeted treatment options for patients.
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Computational and functional screens to find actionable neuroblastoma drivers
Researchers are using advanced computer analysis and lab tests to find new genes and drug targets in neuroblastoma, aiming to improve outcomes for children.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.