Detecting cancer risk and treatment response in NF1 nerve tumors using cfDNA markers

Who could benefit from this research

What this research studies

This project aims to develop noninvasive blood tests that look at cfDNA methylation and chromatin patterns to identify malignant transformation in NF1-associated peripheral nerve sheath tumors. It will create a cfDNA malignancy risk score to distinguish benign from malignant lesions and to track changes during therapy. The research will also use patient-derived tumor models to connect cfDNA signals with tumor growth and drug response, helping guide treatment decisions over time. The investigator will pursue a structured career development plan to grow expertise in cfDNA biomarker development and translational cancer care.

Why it matters

Where this research is happening

• Mayo Clinic Rochester
  Rochester, United States Active

Researchers

• Principal investigator: Szymanski, Jeffrey — Mayo Clinic Rochester
• Study coordinator: Szymanski, Jeffrey

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.