Understanding why sickle cell disease increases the risk of blood cancers.
Mechanisms underlying increased risk of hematological malignancy in sickle cell disease.
This study is looking at why adults with sickle cell disease might have a higher chance of developing blood cancers, and it aims to find out how stress on their cells and DNA damage could play a role, which could help improve treatments for people with sickle cell disease.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11110191 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that lead to a higher risk of hematological malignancies, such as blood cancers, in adults with sickle cell disease (SCD). It focuses on how oxidative stress and DNA damage in hematopoietic stem and progenitor cells may contribute to this increased risk. By conducting experiments in mice, the researchers aim to understand the biological processes involved and how gene therapy and stem cell transplants may influence these risks. The findings could help improve treatment strategies for SCD patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with sickle cell disease, particularly those who have undergone gene therapy or hematopoietic stem cell transplants.
Not a fit: Patients with sickle cell disease who are not adults or have not undergone gene therapy or stem cell transplants may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatments for sickle cell disease, reducing the risk of blood cancers in affected patients.
How similar studies have performed: Previous research has shown that understanding the genetic and biological factors in hematological malignancies can lead to significant advancements in treatment, suggesting potential success for this approach.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Malik, Punam — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Malik, Punam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.