Epigenetic Basis for Controlling Aggressive IDH-Mutant Gliomas
Official title: A Therapeutically Relevant Epigenetic Basis for Restrained Malignancy in IDH-Mutant Gliomas
Funded at State University New York Stony Brook · NIH-11449546 · Data updated 2026-11-12
Aims to understand and shape the epigenetic changes in IDH-mutant brain tumors to restrain their growth, which could lead to new, targeted treatment options for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $566,281 |
| NIH project number | 1R01CA308063-01A1 |
| Project ID | NIH-11449546 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with IDH-mutant gliomas or related brain tumor subtypes could be relevant for future translational studies and trials.
✕Less likely to help
Early-stage basic research may not immediately translate to patient therapies for all participants.
What this research studies
IDH-mutant gliomas have a better prognosis than some other brain tumors, but are still deadly. This project focuses on how DNA methylation and chromatin structure affect gene regulation in these tumors, especially around CDKN2A, PDGFRA, and CDK4. By studying how CTCF insulators and topologically associating domains influence tumor growth, researchers hope to identify new therapeutic angles that could slow or stop tumor progression in patients. The work combines molecular studies with models that reflect human tumor biology to explore how altering these epigenetic features impacts cancer behavior.
Why it matters
Potential benefit: If successful, the research could reveal new targets or strategies to slow or halt tumor growth in IDH-mutant glioma patients.
How similar studies have gone: Preclinical findings have shown that specific epigenetic changes can alter tumor growth, supporting the potential for therapeutic strategies in this area.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Rahme, Gilbert J — State University New York Stony Brook
- Study coordinator: Rahme, Gilbert J
Related research
Other NIH-funded projects on the same topics.
-
Detecting cancer risk and treatment response in NF1 nerve tumors using cfDNA markers
A doctor-led study will test blood-based DNA markers to detect when NF1-related nerve tumors become malignant and to monitor how well treatment is working.
-
US–East Africa center to prevent and detect virus-linked cancers in people with HIV
This program builds a US–East Africa research network to train local investigators and improve prevention, earlier detection, and faster connection to care for virus-related cancers in people with HIV.
-
U.S.–East Africa program to prevent, detect early, and link people with HIV-related cancers to care
This program brings U.S. and East African teams together to help people with HIV by improving prevention, earlier detection, and faster connection to care for cancers linked to the virus.
-
U.S.–East Africa center to prevent and find HIV-related cancers and speed connection to care
This program builds a U.S.–East Africa team to improve prevention, earlier detection, and faster linkage to care for people with HIV at risk for cervical cancer and Kaposi’s sarcoma.
-
Boosting TET Activity to Help Treat AML with Vitamin C
Vitamin C may help people with a type of blood cancer (AML) by boosting a natural anti-cancer pathway, potentially improving outcomes for adults with this disease.
-
Tissue tension and cancer: how stiff tissues drive cancer growth and spread
This NIH grant explores how stiff tissue environments and mechanical forces inside the body may promote cancer growth, aggression, and spread, with the goal of finding biomarkers and new drug targets that could help patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.