Comparing Propofol and Sevoflurane for Children's Tumor Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study investigates the effects of two different anesthesia techniques, propofol intravenous anesthesia and sevoflurane inhalational anesthesia, on pediatric patients undergoing surgery for solid tumor excision. The study aims to evaluate how these anesthetics influence circulating tumor cells, oxidative stress, and biomarkers of immunity, which may impact disease recurrence and survival rates. A total of 100 patients will be randomly assigned to receive either type of anesthesia at Hong Kong Children's Hospital, with a focus on measuring perioperative outcomes over a three-year period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* patients coming for elective primary solid tumor resection for curative intent in Hong Kong Children's Hospital
* AND patients \> 5kg
* AND patients within age limit

Exclusion Criteria:

* Autoimmune / Chronic inflammatory diseases e.g. Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA) etc.
* Current Steroid therapy
* Surgery for tumour removal in the past year
* Allergy to Propofol
* intraoperative use of nitrous oxide
* Patient susceptible to Malignant Hyperthermia
* Patients / parents / legal guardians showing preference in anaesthetic techniques during recruitment process

Where it's running

• Hong Kong Children's Hospital
  Hong Kong, Hong Kong Recruiting

Study contacts

• Principal investigator: Sau Man Lee, MBBS — Hong Kong Children's Hospital
• Study coordinator: Sau Man Lee, MBBS
• Email: lsm335@gmail.com
• Phone: +85257413327

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.