Two thin Percuflex polyurethane stents versus one larger 8Fr silicone stent for malignant ureteral obstruction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Patients with malignant ureteral obstruction will undergo placement of either tandem 6Fr Percuflex polymeric ureteral stents or a single large-caliber 8Fr silicone stent, with clinical follow-up to detect stent failure. The primary outcome is the stent failure rate, defined by symptoms, rising creatinine, or worsening hydronephrosis; secondary outcomes include patient comfort, quality of life, and overall survival. The protocol compares the two endoscopic strategies prospectively at two Israeli tertiary centers to determine which maintains ureteral drainage longer. Data collection will include imaging, laboratory renal function, and patient-reported measures over follow-up visits.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* patient with malignant ureteral obstruction

Exclusion Criteria:

* ureteral obstruction of other causes
* Language comprehension or other limitation in giving informed consent

Where it's running

• Rabin Medical Center
  Petah Tikva, Israel Recruiting
• Sheba medical center
  Ramat Gan, Israel Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.